Institut für Experimentelle Hämatologie und Transfusionsmedizin (IHT)

FVIII Trafficking Dynamics Across Subcellular Organelles Using CRISPR/Cas9 Specific Gene Knockouts
El Hazzouri, Salime; Al-Rifai, Rawya; Surges, Nicole; Rath, Melanie; Singer, Heike; Oldenburg, Johannes; El-Maarri, Osman (2025-07-01)
Factor VIII (FVIII) interacts with Endoplasmic Reticulum (ER) chaperones Calnexin (CANX) and Calreticulin (CALR) and with ER-Golgi Intermediate Compartment (ERGIC) transporters, Lectin, mannose-binding 1 (LMAN1) and Multiple ...
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
Jamil, Muhammad Ahmer; Al-Rifai, Rawya; Nuesgen, Nicole; Altmüller, Janine; Oldenburg, Johannes; El-Maarri, Osman (2024-02-19)
<strong>Introduction:</strong> Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade, and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health implications. Liver ...