Institut für Medizinische Mikrobiologie, Immunologie und Parasitologie (IMMIP)
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Large-scale production of Mansonella perstans infective larvae from engorged Culicoides milnei
Kien, Chi Anizette; Ebai, Rene; Fombad, Fanny Fri; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Chunda, Valerine Chawa; Ekanya, Relindis; Nietcho, Franck Noel; Foyet, Juluis Visnel; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-12-10)<strong>Background:</strong> <em>Mansonella perstans</em> is transmitted by <em>Culicoides</em> species and affects hundred millions of inhabitants in about 33 countries in sub-Saharan Africa. It is known that Mansonellosis ... -
Schistosomiasis–Microbiota Interactions: A Systematic Review and Meta-Analysis
Afful, Philip; Abotsi, Godwin Kwami; Adu-Gyamfi, Czarina Owusua; Benyem, George; Katawa, Gnatoulma; Kyei, Samuel; Arndts, Kathrin; Ritter, Manuel; Asare, Kwame Kumi (2024-10-16)Introduction: Schistosomiasis, a tropical disease affecting humans and animals, affected 251.4 million people in 2021. <em>Schistosoma mansoni, S. haematobium, S. intercalatum</em>, and <em>S. japonicum</em> are primary ... -
Comorbidity profiles among sputum-positive tuberculosis patients in Cameroon
Magha, Chefor; Nchang, Lucy Cho; Weldeslassie, Michael; Nkimbeng, Desmond Akumtoh; Tchatat, Nancielle Mbiatong; Meriki, Henry Dilonga; Deribe, Kebede; Nietcho, Frank Noel; Foyet, Juluis Visnel; Fombad, Fanny Fri; Katcho, Tatiana Djikeussi; Fru Cho, Jerome; Gebremeskel, Eyoab Iyasu; Waddell, Simon J.; Bobosha, Kidist; Newport, Melanie J.; Hoerauf, Achim; Ritter, Manuel; Wanji, Samuel (2024-10-02)<strong>Introduction:</strong> Comorbid non-communicable diseases (NCDs) like diabetes, cardiovascular diseases (CVD), kidney diseases, and hypertension, could have implications for tuberculosis (TB) treatment management ... -
Schistosomiasis endemicity and its role in sexually transmitted infections: A systematic review and meta-analysis
Asare, Kwame Kumi; Afful, Philip; Abotsi, Godwin Kwami; Adu-Gyamfi, Czarina Owusua; Benyem, George; Katawa, Gnatoulma; Arndts, Kathrin; Ritter, Manuel (2024-09-02)<strong>Introduction:</strong> Schistosomiasis, a tropical parasitic disease, affects 779 million people globally, with 85% of cases in Africa. The interplay between schistosomiasis and other sexually transmitted infections ... -
In vitro extracellular replication of Wolbachia endobacteria
Behrmann, Lara Vanessa; Meier, Kirstin; Vollmer, Jennifer; Chiedu, Chukwuebuka Chibuzo; Schiefer, Andrea; Hoerauf, Achim; Pfarr, Kenneth (2024-07-18)Obligate intracellular endobacteria of the genus <em>Wolbachia</em> are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy ... -
Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains
Chunda, Valerine C.; Fombad, Fanny Fri; Kien, Chi Anizette; Ebai, Rene; Esofi, Frederick; Ntuh, Anna Ning; Ouam, Emmanuel; Gandjui, Narcisse Victor Tchamatchoua; Ekanya, Relindis; Nietcho, Franck; Nchang, Lucy Cho; Magha, Chefor; Njouendou, Abdel Jelil; Enyong, Peter; Hoerauf, Achim; Wanji, Samuel; Ritter, Manuel (2024-04-15)<strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ... -
The unusual mode of action of the polyketide glycoside antibiotic cervimycin C
Hoffmann, Alina; Steffens, Ursula; Maček, Boris; Franz-Wachtel, Mirita; Nieselt, Kay; Harbig, Theresa Anisja; Scherlach, Kirstin; Hertweck, Christian; Sahl, Hans-Georg; Bierbaum, Gabriele (2024-05-09)Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by <em>Streptomyces tendae</em> HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a ... -
Is a mass drug administration deworming programme for school-aged children enough to reduce the prevalence of soil-transmitted helminths and Schistosoma mansoni in adults: a cross-sectional study from Togo
Simfele, Hombamane Christelle; Katawa, Gnatoulma; Arndts, Kathrin; Tchopba, Christèle Nguepou; Amessoudji, Oukoe Marthe; Tchadie, Edlom Pélagie; Karou, Simplice Damintoti; Ameyapoh, Yaovi; Hoerauf, Achim; Kolou, Malewe; Layland-Heni, Laura; Ritter, Manuel (2024-02-13)<strong>Background:</strong> The world health organization (WHO) introduced the mass drug administration (MDA) strategy in order to reduce the prevalence of soil-transmitted helminths (STHs) and <em>Schistosoma mansoni</em> ...