Auflistung nach Autor "Wachten, Dagmar"
Anzeige der Dokumente 1-12 von 12
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Action of zona pellucida glycoproteins in mouse and human sperm
Balbach, Melanie (2017-08-22)For fertilization, sperm have to penetrate the oocyte’s vestment, the zona pellucida (ZP). In mouse and human, the ZP consists of three or four different ZP glycoproteins, respectively. Binding of sperm to ZP glycoproteins ... -
Cilia-dependent signaling pathways controlling adipose tissue plasticity
Winnerling, Nora Louise (2022-11-15)Primary cilia serve as cellular antennae that detect extracellular signals and transduce this information into an intracellular response. Dysfunction of primary cilia leads to a range of severe diseases, i.e., the ... -
The Effects of Maternal Obesity on the Innate Immune System: Developmental Programming of Kupffer Cells
Balzer, Nóra Réka (2023-03-29)The global epidemic of obesity has led to an increasing number of obese women in childbearing age. It is now understood that maternal obesity has harmful consequences on fetal and adult health. The underlying mechanism of ... -
Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors
Klausen, Christina; Kaiser, Fabian; Stüven, Birthe; Hansen, Jan N.; Wachten, Dagmar (2019-11-14)The second messenger 3´, 5´-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil ... -
How to control cyclic nucleotide signaling by light
Jansen, Vera; Jikeli, Jan F.; Wachten, Dagmar (2017-03-10)Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has ... -
Investigating the GBA1-dependent regulation of GBA2 activity in Gaucher disease
Schonauer, Sophie (2017-08-01)Glycosphingolipids (GSLs) are a large and heterogeneous class of lipids, whose function is equally versatile and complex. They consist of a membrane anchor, ceramide, and different kinds of sugar head groups. Glucosylceramide ... -
Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue
Silva Ribeiro, Dalila Juliana; Yüksel, Seniz; Dolf, Andreas; Wachten, Dagmar (2023-08-29)Macrophages are one of the prominent leukocyte populations in white adipose tissue (WAT) and play an important role during WAT homeostasis and remodeling. Macrophage function in WAT is determined by ontogeny and the local ... -
Organization and function of signaling molecules in sperm
Hamzeh, Hussein (2017-09-15)Successful fertilization depends on the ability of sperm to locate the egg. Sperm from different species rely on diverse signaling components to gather chemical and physical cues and transduce them into a behavioral swimming ... -
Primary cilia and their effects on immune cell functions and metabolism: a model
Picon-Galindo, Ernesto; Latz, Eicke; Wachten, Dagmar (2022-05)Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed ... -
The primary cilium is a unique lipid microdomain engineered to transduce extracellular cues
Kaiser, Fabian (2022-04-06)Cilia are membrane protrusions located at the surface of almost every vertebrate cell. Cilia come in two different flavors: motile cilia, which generate a fluid flow or propel cells for active movement, and immotile, also ... -
The role of GBA2 in controlling locomotor activity
Woeste, Marina Amelie (2018-12-13)Glycosphingolipids are major constituents of cellular membranes, fulfilling both structural and functional roles. Modifications of the basic glycosphingolipid glucosylceramide (GlcCer) result in numerous complex glycosylated ... -
Shedding light on the role of cAMP in mammalian sperm physiology
Balbach, Melanie; Beckert, Vera; Hansen, Jan N.; Wachten, Dagmar (2018-06-15)Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent ...