Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage
Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage
dc.contributor.author | Weller, Johannes | |
dc.contributor.author | Lampmann, Tim | |
dc.contributor.author | Asoglu, Harun | |
dc.contributor.author | Schneider, Matthias | |
dc.contributor.author | Ehrentraut, Stefan Felix | |
dc.contributor.author | Lehmann, Felix | |
dc.contributor.author | Güresir, Erdem | |
dc.contributor.author | Dorn, Franziska | |
dc.contributor.author | Petzold, Gabor | |
dc.contributor.author | Vatter, Hartmut | |
dc.contributor.author | Zimmermann, Julian | |
dc.date.accessioned | 2023-04-28T11:36:01Z | |
dc.date.available | 2023-04-28T11:36:01Z | |
dc.date.issued | 14.04.2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11811/10801 | |
dc.description.abstract | Cerebrospinal fluid (CSF) metabolites are increasingly recognized as prognostic factors in aneurysmal subarachnoid hemorrhage (SAH). The CSF arginine/ ornithine ratio (Arg/Orn) was shown to predict cerebral vasospasms and clinical outcome in SAH. The additive prognostic value of Arg/Orn over established prognostic scores has not been investigated. CSF Arg/Orn and the established prognostic scores SAH, FRESH, SAH-PDS, HAIR, Rosen–McDonald, Hunt and Hess, WFNS and modified Fisher scale were determined in a prospective cohort of patients with aneurysmal SAH. Logistic regression models to predict a favorable outcome, defined as a modified Rankin Scale score of 0–3 at 3 months follow- up, were constructed for each score, both with and without the addition of Arg/ Orn. The impact of Arg/Orn was assessed comparing logistic regression models containing the respective score with and without Arg/Orn with the likelihood ratio chi-squared test. CSF Arg/Orn and clinical scores were determined in 38 SAH patients. Arg/Orn was an independent predictor of clinical outcome when added to established prognostic scores (p < 0.05) with the exception of HAIR (p=0.078). All models were significantly improved if Arg/Orn was added as a covariable (p<0.05). The results of this study confirm Arg/Orn as an independent prognostic factor and its addition improves established prognostic models in SAH. | de |
dc.format.extent | 6 | |
dc.language.iso | eng | |
dc.rights | Namensnennung 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | subarachnoid hemorrhage | |
dc.subject | outcome prognostication | |
dc.subject | ornithine | |
dc.subject | arginine | |
dc.subject | scores accuracy | |
dc.subject | cerebrospinal fluid | |
dc.subject | arginase 1 | |
dc.subject.ddc | 610 Medizin, Gesundheit | |
dc.title | Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage | |
dc.type | Wissenschaftlicher Artikel | |
dc.publisher.name | Frontiers | |
dc.rights.accessRights | openAccess | |
dcterms.bibliographicCitation.volume | 2023, vol. 14 | |
dcterms.bibliographicCitation.pagestart | 1 | |
dcterms.bibliographicCitation.pageend | 6 | |
dc.relation.doi | https://doi.org/10.3389/fneur.2023.1156505 | |
dcterms.bibliographicCitation.journaltitle | Frontiers in Neurology | |
ulbbn.pubtype | Zweitveröffentlichung | |
dc.version | publishedVersion | |
ulbbn.sponsorship.oaUnifund | OA-Förderung Universität Bonn |
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