Suen, Tsz Kin: The Immune Memory Response and Metabolic Requirements of Human Gamma Delta T Cells. - Bonn, 2024. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5-76107
@phdthesis{handle:20.500.11811/11531,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5-76107,
author = {{Tsz Kin Suen}},
title = {The Immune Memory Response and Metabolic Requirements of Human Gamma Delta T Cells},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2024,
month = may,

note = {γδ T cells are unconventional T cells that can mediate pro-inflammatory, cytotoxic, phagocytotic and professional antigen presenting properties. Sharing the features of both adaptive and innate immunity, γδ T cells also showed signs of induction of both adaptive immune memory and innate immune memory responses. These multi-functional cells therefore play indispensable roles in acquired immunity, host defense against infection and immune surveillance against cancer. In the first part of this thesis, I reviewed the concept and recent advances of innate immune memory and showed the discovery of the trained immunity phenotype in γδ T cells by BCG and MMR vaccination, demonstrating for the first time that γδ T cells can mount both adaptive and innate memory. In the second part of the thesis, I focused on investigating the effect of manipulating mevalonate metabolism on the immune function of γδ T cells as well as the metabolic and immune functional changes of γδ T cells in autoinflammatory and immunodeficient disorders. The result of these studies encouraged us to take into account the adverse effects of mevalonate pathway inhibitors on gd T cells and provided possible reasons for the limited effectiveness and efficiency of the current γδ T cellbased therapy. Altogether, my thesis offered additional knowledge to facilitate the development of next-generation vaccines and a better γδ T cell-based therapy for cancer and infectious diseases in the future.},
url = {https://hdl.handle.net/20.500.11811/11531}
}

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