Molecular and Immunological Mechanisms Underlying Inflammation during SARS-CoV-2 Infection
Molecular and Immunological Mechanisms Underlying Inflammation during SARS-CoV-2 Infection
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DissertationPrüfungsdatum
09.09.2025Datum der Veröffentlichung
25.09.2025Erstgutachter
Latz, EickeZweitgutachter
Bedoui, SammyMetadaten
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Inhalt
This thesis explores the immune mechanisms activated during SARS-CoV-2 infection across different disease severities through a comprehensive multi-omics approach. It specifically emphasizes the role of peripheral monocytes, investigating their programming during infection using bulk RNA-Sequencing. Additionally, the study delves into the development of antibodies in response to both infection and vaccination against the virus. Through single-cell RNA sequencing, it further deciphers the immune pathways activated in various immune cells within peripheral blood. This research provides valuable insights into the complex immune responses to SARS-CoV-2, connected to low interferon response, antigen presentation and highly pro-inflammatory state of severe COVID-19 patients.
Schlagwörter
SARS-CoV-2, COVID-19, Entzündung, Monozyten, Einzelzell-RNA-Sequenzierung, Bulk-RNA-Sequenzierung, Antikörperantwort, Impfung, Zytokine, Immunologie, SARS-CoV-2, COVID-19, single cell RNA sequencing, bulk RNA sequencing, monocytes, inflammation, antibody response, vaccination, cytokines, immunology
Klassifikation (DDC)
610 Medizin, GesundheitZugehörige Publikation(en)
https://doi.org/10.3390/ijms232012231Odainic, Alexandru: Molecular and Immunological Mechanisms Underlying Inflammation during SARS-CoV-2 Infection. - Bonn, 2025. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, University of Melbourne.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5-85136
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5-85136
@phdthesis{handle:20.500.11811/13463,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5-85136,
doi: https://doi.org/10.48565/bonndoc-655,
author = {{Alexandru Odainic}},
title = {Molecular and Immunological Mechanisms Underlying Inflammation during SARS-CoV-2 Infection},
school = {{Rheinische Friedrich-Wilhelms-Universität Bonn} and {University of Melbourne}},
year = 2025,
month = sep,
note = {This thesis explores the immune mechanisms activated during SARS-CoV-2 infection across different disease severities through a comprehensive multi-omics approach. It specifically emphasizes the role of peripheral monocytes, investigating their programming during infection using bulk RNA-Sequencing. Additionally, the study delves into the development of antibodies in response to both infection and vaccination against the virus. Through single-cell RNA sequencing, it further deciphers the immune pathways activated in various immune cells within peripheral blood. This research provides valuable insights into the complex immune responses to SARS-CoV-2, connected to low interferon response, antigen presentation and highly pro-inflammatory state of severe COVID-19 patients.},
url = {https://hdl.handle.net/20.500.11811/13463}
}
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5-85136,
doi: https://doi.org/10.48565/bonndoc-655,
author = {{Alexandru Odainic}},
title = {Molecular and Immunological Mechanisms Underlying Inflammation during SARS-CoV-2 Infection},
school = {{Rheinische Friedrich-Wilhelms-Universität Bonn} and {University of Melbourne}},
year = 2025,
month = sep,
note = {This thesis explores the immune mechanisms activated during SARS-CoV-2 infection across different disease severities through a comprehensive multi-omics approach. It specifically emphasizes the role of peripheral monocytes, investigating their programming during infection using bulk RNA-Sequencing. Additionally, the study delves into the development of antibodies in response to both infection and vaccination against the virus. Through single-cell RNA sequencing, it further deciphers the immune pathways activated in various immune cells within peripheral blood. This research provides valuable insights into the complex immune responses to SARS-CoV-2, connected to low interferon response, antigen presentation and highly pro-inflammatory state of severe COVID-19 patients.},
url = {https://hdl.handle.net/20.500.11811/13463}
}
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