E-Dissertationen: Browsing E-Dissertationen by Title
Now showing items 784-803 of 4162
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Design und Synthese neuartiger Inhibitoren für den ABC-Transporter Breast Cancer Resistance Protein
Steggemann, Kerstin (2011-05-31)P-Glykoprotein (P-gp/ABCB1) und das Breast Cancer Resistance Protein (BCRP/ABCG2) sind humane ABC-Transporter mit einer multispezifischen Substraterkennung. Sie werden verstärkt an physiologischen Barrieren exprimiert und ... -
Design und Synthese von Rotaxanen für die Einzelmolekül-Spektroskopie und massenspektrometrische Untersuchungen von Guanosin-Quartetts
Illigen, Jens (2007)Im Rahmen dieser Arbeit sollte die Entwicklung und Synthese eines Rotaxans für die Einzelmolekül-Spektroskopie erfolgen. Hierzu wurden die benötigten Bedingungen analysiert. Diese Erkenntnisse flossen anschließend erfolgreich ... -
Design, Assembly and Triggering of Interlocked DNA Nanoarchitectures
Lohmann, Finn (2015-09-25)Interlocked molecular systems are well known in supramolecular chemistry and are widely used for various applications like sensors, molecular machines and logic gates. However, these systems present some drawbacks, as the ... -
Design, assembly, and operation of a self-regulating DNA rotaxane linear actuator
Yu, Ze (2022-04-07)DNA is not only the carrier of genetic information but also an excellent bottom-up material for constructing nanostructures due to its high degree of programmability. Interlocked DNA nanostructures have a potential use as ... -
Design, Aufbau und Test einer neuen Ausleseelektronik für das Crystal-Barrel-Kalorimeter
Honisch, Christian (2015-08-28)Die Baryonspektroskopie stellt eine gute Möglichkeit dar, Vorhersagen von Quarkmodellen und modernen Gitter-QCD-Rechnungen zu prüfen und so die Quantenchromodynamik (QCD) im nicht pertubativ lösbaren Energiebereich zu ... -
Design, Entwicklung und Herstellung modifizierter gastroretentiver schwimmender Systeme auf Basis von schmelzextrudierten hohlen Zylindermatrices
Simons, Fabian Josef (2020-04-15)Die Entwicklung gastroretentiver Arzneiformen ist komplex, da neben der kontrollierten Freisetzung des Wirkstoffs zusätzlich die Verlängerung der Verweilzeit im Magen gewährleistet werden muss. Hierfür werden meist hydrophile ... -
Design, Synthese und 3D-QSARneuartiger P-gp-Modulatoren
Klinkhammer, Werner (2006)Resistenzen gegenüber verschiedensten Arzneimitteln sind ein steigendes Problem in der Therapie von Krankheiten. Das Phänomen der Multidrug-Resistenz (MDR) tritt besonders im Zusammenhang mit der Therapie von malignen ... -
Design, Synthese und Biologische Testung neuartiger Chalkon-Derivate als ABCG2 Inhibitoren
Kraege, Stefanie (2017-04-24)Multidrug Resistenz (MDR) von Krebszellen, verursacht durch eine gesteigerte Expression von ABC Transportern, zählt zu den Gründen für das Scheitern einer Chemotherapie. Die Entwicklung potenter und selektiver Inhibitoren ... -
Design, synthesis and optimization of nucleotide-derived inhibitors and probes for the ecto-nucleotidases CD39 and CD73
Schmies, Constanze Cerine (2019-12-04)Cell damage or cell lysis as a consequence of organ injury, shock, or inflammtory conditions leads to a massive release of intracellular ATP. ATP activates purinergic P2Y and P2X cell membrane receptors. ATP signaling is ... -
Design, synthesis and optimization of receptor ligands: tools for studying purine-activated and related orphan G protein-coupled receptors
Harms, Tim (2022-04-01)<strong>Adenosine receptors</strong> <br /> The A<sub>2A</sub> and A<sub>2B</sub> adenosine receptors (ARs) are promising drug targets in Alzheimer´s and Parkinson´s disease, inflammatory diseases, autoimmune diseases, ... -
Design, synthesis and pharmacological evaluation of nucleotidic and non-nucleotidic inhibitors and probes for the ecto-5'-nucleotidase (CD73)
Rolshoven, Georg Wilhelm (2022-03-22)Ecto-5'-nucleotidase (CD73) plays a central role in the metabolic breakdown of extracellular AMP. The enzyme is attached to the cell membrane by a glycosylphosphatidylinositol anchor, but can also be released by shedding, ... -
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
Marx, Daniel (2021-04-12)The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ... -
A detailed investigation of clear cell renal cell carcinoma cell and organoid cultures to find putative therapeutic targets and novel therapy approaches
Eßer, Laura Kristin (2022-06-20)Therapy options for metastasized renal cell carcinoma are limited. While immune checkpoint inhibitors and therapies targeting the tumor microenvironment have drastically changed treatment options, response rates are hardly ... -
A Detailed Study of Galaxy Clusters with Weak Gravitational Lensing and X-rays
Piel, Jennifer Miriam (2012-07-17)Galaxy clusters represent the top of hierarchical structure formation with the largest dark matter halos. Their abundance with respect to mass and redshift can be used to constrain cosmological parameters. The most extensive ... -
Detailed X-ray properties of galaxy groups and fossil groups
Vijaysarathy, Bharadwaj (2015-09-16)Most galaxies in the Universe are aggregated into groups of galaxies, agglomerations of a few 10s of galaxies at most. For long they have been considered to be very similar to clusters, which contain a few 100s of galaxies. ... -
Details of the immune response and impact of the microbiome in murine calcific aortic valve stenosis
Rodrigo, Maria Belen (2023-06-26)(noch nicht zugänglich / not yet accessible) -
Detecting Plant Functional Traits of Grassland Vegetation Using Spectral Reflectance Measurements
Hollberg, Jens Lothar (2018-03-06)Changes in climate and an intensified agricultural use threaten grassland ecosystems in many places. To allow an efficient conservation of grassland vegetation communities, ecologists monitor variations in their plant ... -
Detection and quantification of permafrost change in alpine rock walls and implications for rock instability
Krautblatter, Michael (2010-01-08)The perennial presence of ice in permafrost rock walls alters thermal, hydraulic and mechanic properties of the rock mass. Temperature-related changes in both, rock mechanical properties (compressive and tensile strength ... -
Detection and Simulation of Dangerous Human Crowd Behavior
Krausz, Barbara (2013-01-09)Tragically, gatherings of large human crowds quite often end in crowd disasters such as the recent catastrophe at the Loveparade 2010. In the past, research on pedestrian and crowd dynamics focused on simulation of pedestrian ... -
Detection of Legionella pneumophila and Pseudomonas aeruginosa and biofilm experiments in four different cooling towers (construction and biocide treatment) and evaluation of IDEXX most probable number methods in industrial water samples
Spies, Kirsten (2021-11-30)The responsible maintenance of evaporative cooling systems is an essential element in reducing the risk of the environmental dispersion of legionellae and Legionnaires’ disease outbreaks. In Germany, the 42nd Ordinance ...