E-Dissertationen: Auflistung E-Dissertationen nach Titel
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Comparison of a global submission of new biological entity and a new chemical entity: strategic decisions and criteria for implementation
(2011-06-09)The world covers more than 190 countries in which at the moment in most of them pharmaceutical legislations and regulatory requirements are established and implemented, e.g. to describe the marketing authorization (MA) ... -
Comparison of human and porcine aortic valve endothelial and interstitial cells
(2024-02-13)Calcific aortic valve disease (CAVD) is one of the most common heart valve pathologies and a major cause of morbidity and mortality in the elderly population. The disease is characterized by the gradual accumulation of ... -
Compartmentalisation of cAMP in Brown Adipocytes
(2022-02-14)The second messenger, 3',5'-cyclic adenosine monophosphate (cAMP) plays an important role in governing the function and differentiation of brown adipocytes. Upon the stimulation of G<sub>s</sub>-coupled G protein-coupled ... -
Complement receptors 3 and 4 in kidney diseases
(2023-12-11)CR3 and CR4 are among the most abundant molecules on the cell surface of DCs, monocytes/macrophages, and PMNs. Both integrins recognize common ligands among which are iC3b, ICAM-1, and fibrinogen. iC3b is generated as a ... -
Complement-mediated neuronal loss by sialic acid glycocalyx alterations
(2018-04-23)Every neuronal cell is covered with a dense structure of glycoconjugates, the glycocalyx. Sialic acids form the terminal ends of the glycocalyx and thus, are more accessible for the cellular environment. Microglia, the ... -
Complementary adaptations of bacterial membranes to low temperatures
(2022-08-31)The membrane of bacteria is a crucial component that separates the cell from its environment and forms the site of essential functions such as energy generation, nutrient uptake, and sensing. Some bacteria can adapt their ... -
The complete experiment problem of pseudoscalar meson photoproduction in a truncated partial wave analysis
(2019-02-07)One of the remaining open challenges in Standard Model phenomenology is the formation of bound states of quarks in the strong coupling regime of Quantum Chromodynamics (QCD). This is true in particular for the excited ... -
Complex Multiplication, Rationality and Mirror Symmetry for Abelian Varieties and K3 Surfaces
(2007)This thesis consists of three parts. In the first part we study abelian varieties and K3 surfaces of CM-type (i.e. their Hodge group is commutative), aiming at a characterization of complex multiplication via the existence ... -
Complex organic chemistry in high-mass star forming regions
(2019-10-22)The quest for interstellar complex organic molecules (COMs) lies at the heart of astrochemistry. One basic motivation is to figure out how the rich inventory of COMs found in meteorites and comets is connected to interstellar ... -
Complexity Bounds on Some Fundamental Computational Problems for Quantum Branching Programs
(2005)We study quantum computational complexity of several problems connected to the Hidden Subgroup Problem. This problem drew substantial attention when a polynomial time quantum algorithm for it was found. The algorithm ... -
Component-based Adaptation Methods for Service-Oriented Peer-to-Peer Software Architectures
(2007)Service-oriented peer-to-peer architectures aim at supporting application scenarios of dispersed collaborating groups in which the participating users are capable of providing and consuming local resources in terms of peer ... -
Composite Finite Elements for Trabecular Bone Microstructures
(2010-11-19)In many medical and technical applications, numerical simulations need to be performed for objects with interfaces of geometrically complex shape. We focus on the biomechanical problem of elasticity simulations for trabecular ... -
Comprehensive population synthesis predictions for massive binary stars in the Small Magellanic Cloud
(2024-01-30)The past and ongoing gravitational wave detections have fostered a wide interest in understanding the formation of binary black holes (BBHs). Several formation scenarios have been proposed, including the evolution of ... -
Computation of Electronic Excitation Spectra of Large Biomolecular Systems
(2020-11-30)This thesis presents the theoretical investigation of electronic excitation spectra and nonlinear responses of large biomolecular systems (e.g., proteins or deoxyribonucleic acid fragments), with a particular focus on the ... -
Computation of Mass Spectra Using Quantum Chemical Methods
(2022-11-23)Mass spectrometry (MS) is widely used for the structural elucidation of compounds in a vast variety of scientific research. Unfortunately, many methods that aim to predict mass spectra cannot often elucidate the complete ... -
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
(2019-06-21)Compound promiscuity offers both opportunities and perils for medicinal chemistry and drug discovery. On the one hand, it is well-established that compounds elicit their therapeutic potential by engaging with multiple ... -
Computational Analysis of Pathophysiological Mechanisms Based on Pathway Modeling
(2019-12-18)The advent of the big data era poses major challenges to the biomedical domain. First, it is necessary to adopt strategies that integrate and link the heterogeneous resources that contain multiscale and multimodal data in ... -
Computational Analysis of Structure-Activity Relationships: From Prediction to Visualization Methods
(2012-07-18)Understanding how structural modifications affect the biological activity of small molecules is one of the central themes in medicinal chemistry. By no means is structure-activity relationship (SAR) analysis a priori ... -
Computational Electrochemistry of 3d Transition Metal Complexes
(2024-02-05)The topic of this thesis is the computational quantum chemical (QC) description of homogeneous first-row (3d) transition metal (TM) electrocatalysis. This branch of chemistry holds great potential for employing Earth-abundant ... -
Computational Exploration of Virus Diversity on Transcriptomic Datasets
(2019-11-21)Most of the ongoing virus research is focused on mammalian and bird viruses, which are well known to be directly or indirectly associated with human diseases. While many viruses are transmitted by blood-feeding arthropods ...
