E-Dissertationen: Auflistung E-Dissertationen nach Autor "Lang, Thorsten"
Anzeige der Dokumente 1-20 von 26
-
Alkyne lipid probes and azide detection reagents for in vitro enzymatic assays and highly sensitive lipid imaging
Gäbler, Anne (2015-08-28)Click chemistry has emerged as a powerful tool for the sensitive and specific labeling of biomolecules in various applications. For the design of lipid probes, a small and non-interfering tag is important to prevent ... -
Bildungsmechanismus und physiologische Relevanz supramolekularer Proteincluster des Amyloid Precursor Protein APP in der Zellmembran
Schreiber, Arne (2013-01-09)Proteine in biologischen Membranen sind in der Regel heterogen in Domänen organisiert. Die Mechanismen dieser Segregation in Membranproteincluster unterschiedlicher Zusammensetzung sind noch immer unverstanden. <br /> Auch ... -
Binding of cytohesin 2 to the plasma membrane and its relationship with the EGFR
Karnowski, Nora (2018-11-06)Eukaryotic cells are compartmentalized by lipid membranes to achieve the spatial separation of biological processes and signaling pathways. Controlled trafficking of proteins between these compartments as well as the ... -
Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
Lechner, Hildegard (2009-05-13)Gap junctions channels serve as mediators for direct cell-to cell communication between cells of different tissues and organs by the exchange of small metabolites and signalling molecules. They are formed by analogous ... -
Concentration Dependent Ion–Protein Interaction Patterns Underlying Protein Oligomerization Behaviours
Batoulis, Helena (2017-07-27)Most proteins do not exist as monomers. Instead, proteins assemble into oligomeric structures, which range from small dimers to intermediately sized clusters to large polymers. Oligomerization is driven by protein–protein ... -
Coupling of Proton Transfer and Multidrug Expulsion in the Inner Membrane Translocase AcrB
Fischer, Nadine (2013-07-24)With the introduction of the first antibiotics in the 1940s, lethal bacterial infections like tuberculosis or pulmonary inflammation were widely believed to be defeated. However, bacteria inherently hold a variety of ... -
Cytohesins are cytoplasmic ErbB receptor activators
Bill, Anke (2011-07-12)Signaling by ErbB receptors requires the activation of their cytoplasmic tyrosine kinase domains which is initiated by ligand binding to the receptor ectodomains. Up to now, cytoplasmic factors contributing to the activation ... -
Dynamic organization and interactions of plasmalemmal SNARE proteins studied in plasma membrane sheets and live cells
Halemani, Nagaraj D. (2012-04-05)All Eukaryotic cells and their internal organelles are surrounded by membranes. Many cellular functions involve transport of material between membrane bound compartments initiated by a fusion step of respective membranes. ... -
Electrostatic anchoring of SNAP25 to the plasma membrane
Weber, Pascal (2021-07-21)Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ... -
Interplay between the amyloid precursor protein (APP) and α-secretases at the plasma membrane
Hitschler, Lisa (2022-04-21)Alzheimer’s disease (AD) is the most common form of dementia. A principle pathological feature of AD are senile plaques consisting of extracellular aggregations of amyloid β peptides (Aβ). Aβ is derived from the amyloid ... -
Kontrolle der lateralen Organisation von Membranproteinen
Walrafen, David Jan (2012-06-12)In den letzten Jahrzehnten wurde bei Untersuchungen an Zellmembranen deutlich, dass viele Membranproteine nicht, wie ursprünglich angenommen, homogen verteilt sind, sondern in Mikrodomänen organisiert vorkommen. Die ... -
Membrane-model systems to study EGFR-ARNO interaction
Bettio, Martina (2017-01-04)Transmembrane proteins are involved in important biological functions, such as in transport of molecules, and in signal transduction. They represent almost 25 % of the proteome and constitute important drug targets. The ... -
The mesoscale organization of Syntaxin 1A and SNAP25 at the plasma membrane
Mertins, Jasmin (2023-03-09)The plasma membrane is a highly crowded place consisting of a plethora of proteins and lipids, which show a high degree of micropatterning. Most proteins are not homogeneously distributed but concentrated in clusters. ... -
Molecular function of RIM1α: role of phosphorylation sites
Müller, Johannes Alexander (2020-04-22) -
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
Riffel, Florian Raphael (2024-01-22)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ... -
New inhibitory pathways in CD8 T cell function
Mikulec, Julita (2016-06-07)An adaptive immune response is initiated upon recognition of antigen presented on the surface of antigen-presenting cell (APC) by T cells. CD8 T cells primed in the liver by antigen-presenting liver sinusoidal endothelial ... -
Novel aspects regarding structural variability in membrane protein families by the example of tetraspanins
Reppert, Nikolas (2022-11-16)The work at hand focuses on structural variability in membrane protein families by the example of tetraspanins. The family of tetraspanins is found in almost all multicellular organisms and they play important roles in an ... -
Organization and function of signaling molecules in sperm
Hamzeh, Hussein (2017-09-15)Successful fertilization depends on the ability of sperm to locate the egg. Sperm from different species rely on diverse signaling components to gather chemical and physical cues and transduce them into a behavioral swimming ... -
Phosphatidylcholine is organized in long-lived plasmalemmal platforms
Spitta, Luis Fernando (2013-03-13)All living cells are enclosed by a membrane that is mainly made up of proteins and lipids. The lateral organization of these constituents is a subject in current research. It has been discussed since two decades whether ... -
Physikochemische und biochemische Mechanismen in der Plasmamembran zur Kontrolle des Clusterverhaltens des T-Zell-Rezeptors
van Üüm, Jan Niklas (2014-02-26)Die Plasmamembran als Vermittlerin zwischen Zellinnerem und umgebender Umwelt ist eine wichtige Struktur der Zelle, deren Organisationsprinzipien nur ansatzweise verstanden sind. Membranproteine erfüllen essentielle Aufgaben ...