E-Dissertationen: Browsing E-Dissertationen by Author "Magin, Thomas M."
Now showing items 1-8 of 8
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Activity-Dependent Regulation of Neuronal Ion Channel Expression During Epileptogenesis
Chen, Jian (2005)Status epilepticus (SE) is known to cause numerous structural and functional alterations in brain. In this study, expression of various voltage-gated ion channels in rat hippocampal CA1 neurons were investigated at different ... -
Altered signaling, but no cell fragility in mice lacking all type II keratin genes
Vijayaraj, Preethi (2008)<p>Keratins are major cytoskeletal proteins of epithelia, organized in two large gene families of 28 (type I) and 26 (type II) members spanning 1.2 Mb and 0.68 Mb of genomic loci, respectively. Their expression is tightly ... -
Contributions of keratins to epithelial cell architecture and signaling
Kröger, Cornelia (2011-07-04)Keratin intermediate filament proteins form the major cytoskeleton in all epithelia. Increasing evidence suggests that keratins act as cytoskeletal scaffolds which locally regulate cell growth and survival. Many of these ... -
Copy number variations of the mitochondrial DNA as potential cause of mitochondrial diseases
Baron, Miriam (2010-12-30)Aim: The aim of this thesis was the analysis of copy number variations of the mitochondrial DNA (mtDNA) in several tissues and cell types with regard to different mitochondrial associated disorders.<br /> Background: The ... -
Identification and characterization of novel keratin associated proteins using a genetic interaction screening system
H.C, Prashanth (2009-07-21)Keratins are an integral and important constituent of the epithelial cytoskeleton and protect epithelial cells against stress. In addition to their well-established function as cytoskeletal scaffolds in epithelia, recent ... -
Identifikation und Charakterisierung differenziell exprimierter Gene in einer Mausmutanten mit prolongierter Engrailed-2 Expression mithilfe der Array-Technologie
Holst, Martin Ingo (2007)Die Überexpression von Engrailed-2 in den Purkinjezellen des Kleinhirns der L7En-2 Maus führt zu einem cerebellären Phänotyp, der bisher auf morphologischer Ebene gut untersucht ist, dessen genetischer, physiologischer und ... -
Identifikation von Vimentin als humanes Katarakt-Gen
Müller, Martin (2009-11-02)Vimentin ist das IF-Protein in den Zellen mesenchymalen Ursprungs. In bisherigen in vivo und in vitro Untersuchungen wurde noch kein Bezug zwischen Vimentin und einer spezifischen humanen Erkrankung gezeigt. In der ... -
Untersuchungen zur Funktion des Intermediarfilamentproteins Vimentin in vivo
Meier-Bornheim, Roland (2006)Vimentin ist ein Intermediarfilament-Protein (IF) und wird in unterschiedlich differenzierten Zellen mesenchymalen Ursprungs exprimiert. Zudem ist Vimentin das Haupt-IF im Epithel und den kortikalen Faserzellen der Linse. ...