E-Dissertationen: Browsing E-Dissertationen by Author "Mandelkow, Eckhard"
Now showing items 1-4 of 4
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Development of oligomer-specific antibodies against tau protein and testing of therapeutic potential in a cell model of tau pathology
Chandupatla, Ram Reddy (2020-04-15)Tau, a microtubule associated protein, forms abnormal aggregates in many neurodegenerative diseases such as Alzheimer disease (AD). There is an urgent need for disease-modifying therapies of AD and related tauopathies. ... -
Propagation of Tau pathology in Alzheimer disease
Ferreira Rodrigues, Sara (2020-09-10)Clinical and experimental evidences suggest that the spreading of tau protein throughout the brain may underlie the stereotypical progression of pathology in the brains of Alzheimer disease (AD) patients and concomitant ... -
Sorting, missorting and spreading of Tau in neurons studied in microfluidic chambers
Balaji, Varun Venkatesh (2017-09-04)Tau is a microtubule-associated protein which plays an important role in stabilizing microtubules (Mandelkow and Mandelkow, 2012). Tau is mainly an axonal protein but it is missorted into the somatodendritic compartment ... -
Structural and Functional Characterization of Neurotoxic Oligomers of Pro-aggregant Tau Repeat Domain: A model for Tauopathy disease
Kaniyappan, Senthilvelrajan (2016-04-26)Tau protein is a microtubule associated protein present abundantly in the neurons of the central nervous system where it stabilizes the axonal microtubules thereby providing structural architecture for the axons of neurons. ...