E-Dissertationen: Browsing E-Dissertationen by Author "Odermatt, Benjamin"
Now showing items 1-5 of 5
-
Charakterisierung von gpr17 und dessen Einfluss auf die Myelinisierung im Zebrafisch (Danio rerio)
Kleinert, Henning (2018-06-05)Der Zebrafisch <em>(Danio rerio)</em> ist ein karpfenartiger Süßwasserfisch, der sich aufgrund seiner schnell voranschreitenden Embryogenese und der Transparenz der Embryonen bis zum 5. Tag nach der Befruchtung der Eizelle ... -
Classic Bladder Exstrophy: identification of genetic markers and characterization of its associated ISL1 gene
Mingardo, Enrico (2024-09-24)Classic bladder exstrophy (CBE) is a congenital anomaly with an occurrence of 1 in 30.000 new born. It is characterized by the protrusion of the bladder plate through an open abdominal wall, often accompanied by kidney and ... -
A humanized zebrafish screening platform to identify GPR17 inhibitors for the treatment of multiple sclerosis
Häberlein, Felix (2020-02-19)Multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS) with dev-astating symptoms, is characterized by the progressive destruction of myelin and myelinating oligodendrocytes (Ol). Currently, ... -
Investigating the function of 36K – a major CNS myelin protein in zebrafish
Nagarajan, Bhuvaneswari (2019-02-14)Zebrafish can regenerate and remyelinate CNS axons following injury in contrast to humans and other mammals. Common myelin proteins like Mbp, Plp1/DM20 are conserved across species from zebrafish to humans. In addition to ... -
Zebrafish as a Model Organism to Study the In Vivo Role of G-Protein Coupled Receptor 17 in Myelination
Schmitt, Nina-Katharina (2019-02-26)The sheathing of axons with myelin by oligodendrocytes constitutes a necessity for sufficient and rapid nerve conduction within the vertebrate central nervous system (CNS). However to date, the complex molecular mechanisms ...