E-Dissertationen: Browsing E-Dissertationen by Author "Oldenburg, Johannes"
Now showing items 1-10 of 10
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Characterization of the structural-functional impact of heterozygous missense mutations in genes of the blood coagulation factor XIII that cause mild Factor XIII deficiency
Thomas, Anne (2018-01-04)The coagulation Factor XIII is a key player in hemostasis that is responsible for the last step of the coagulation cascade in which it covalently cross-links preformed fibrin clots to make them resistant to premature ... -
Characterization of VKORC1L1 with respect to VKORC1
Liphardt, Kerstin (2019-07-10)Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ... -
Funktionelle Untersuchung der Vitamin K 2,3-Epoxid-Reduktase
Czogalla, Katrin Jeannette (2014-02-05)Seit 1941 werden Cumarine als orale Antikoagulantien in der Therapie venöser und arterieller Thrombosen sowie zur Prävention thromboembolischer Ereignisse bei z.B. Herz-Kreislauf-Erkrankungen eingesetzt. Trotz der jahrelangen ... -
Funktionelle Untersuchungen zur zellulären Antioxidation und Lokalisierung der Vitamin K 2,3-Epoxid Reduktase C1 L1
Westhofen, Philipp (2010-11-17)Durch systematische und funktionelle Charakterisierung der VKORC1L1 wurde im Rahmen dieser Arbeit ein neuer elementarer zellulärer Stoffwechselmechanismus zur Abwehr von oxidativem Stress beschrieben. Dieser Mechanismus ... -
Identifying Genetic Basis and Molecular Mechanisms in Different Types of von Willebrand Disease (VWD)
Yadegari, Hamideh (2013-08-22)Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It is caused by quantitative or qualitative defects of the von Willebrand factor (VWF) which has crucial roles in hemostasis. VWD is classified ... -
The interplay of differentially γ-carboxylated vitamin K dependent proteins constitute variable VKCFD1 phenotypes
Ghosh, Suvoshree (2021-11-18)Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated with high dose of vitamin K, ... -
Investigation of new mechanisms causing hemophilia A
Pezeshkpoor, Behnaz (2014-02-05)The main aim of this work was identification of novel molecular mechanisms causing hemophilia A, with a special focus on patients without detectable mutation. In most of hemophilia A patients, mutations could be identified ... -
Methylierungsmarker zur Identifizierung von Körperflüssigkeiten und Geweben aus forensischem Spurenmaterial
Forat, Sophia (2015-01-06)Biologische Tatortspuren sollen helfen Täter zu identifizieren und einen Tathergang zu rekonstruieren. Letzteres erreicht man sehr häufig durch eine eindeutige Beschreibung des Gewebes oder der Flüssigkeit, aus der die ... -
Structural and functional characterization of human coagulation factor XIII
Singh, Sneha (2020-06-02)The formation of a fibrin clot in blood plasma is a two-step event which involves formation of a “primary clot” comprising of fibrin polymers by from fibrin monomers under the action of thrombin and subsequently the ... -
Vitamin K1 pharmacokinetics in a clinical study and VKORC1 enzyme kinetics using HPLC methodology
Marinova, Milka (2013-04-04)The main objective of the present work by means of a phase I clinical study was to determine inter-individual variance in pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation in ...