E-Dissertationen: Search
Now showing items 71-80 of 85
Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
(2019-07-22)
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Platelet-immune cell interactions in inflammation and cancer
(2019-09-10)
Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ...
Characterization of VKORC1L1 with respect to VKORC1
(2019-07-10)
Vitamin K reduction is essential and catalyzed by two enzymes in vitro. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K to sustain γ-carboxylation of vitamin K dependent (VKD) proteins. This ...
Qualität der Kundeninformationen von Herstellern bei korrektiven Maßnahmen zu In-vitro Diagnostika: Analyse der vom BfArM 2005 bis 2014 publizierten Daten
(2018-08-15)
In dieser Arbeit wurden erstmals die gesamten auf der Homepage des BfArM publizierten Kundeninformationen zu korrektiven Maßnahmen bei In-vitro Diagnostika auf Inhalt und Qualität überprüft. Der Vergleich mit den Rote Hand ...
Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors
(2018-08-28)
Globally, cancer is the second leading cause of death. Chemotherapy is commonly used in the treatment of cancer. However, in clinic, a wide variety of cancers display resistance to chemotherapy leading to the failure of ...
Cisplatin resistance is associated with altered signalling in NSCLC cells
(2018-01-18)
The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the mechanisms underlying acquired cisplatin resistance, the ...
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
(2019-02-07)
The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ...
Protein and epigenetic biomarkers for variability in epidermal growth factor receptor inhibition in cancer treatment and characterization of the inhibitor-induced skin toxicity in an in vitro model
(2019-01-31)
Epidermal growth factor receptor (EGFR) is often over-expressed or over-activated in cells of solid tumors and can be targeted by specific inhibitors (EGFRIs), like erlotinib, gefitinib, cetuximab and panitumumab. ...