E-Dissertationen: Suche
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Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis tolerate Toll-like receptor 2-specific activation
(2021-01-26)
Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The skin of AD patients shows a significant dysbalance of the microbiome with high colonization of S. aureus, which positively correlates with ...
Improving solubility and supersaturation of poorly soluble drugs using solid dispersions based on natural polymers and mixtures thereof
(2021-05-19)
The poor solubility of existing drug substances and new chemical entities is a problem in modern pharmaceutical development. There are various strategies to overcome the solubility limited bioavailability of poorly soluble ...
State-dependent processing of Dentate Gyrus granule cell activity in-vivo
(2020-12-16)
The ability to form dissimilar neural activity patterns from similar sensory driven inputs is a phenomenon found in all vertebrates, called pattern separation. In mammals, pattern separation is closely related to a subregion ...
From galaxies to the cosmic web and back: the interplay of different scales in galaxy formation and cosmic reionization
(2020-10-08)
The evolution of the Universe is primarily governed by gravity, that triggers the development of a complex web-like distribution of galaxies. The latter are embedded in larger structures, called haloes, mainly composed by ...
The influence of G-quadruplex structures on meiosis
(2021-01-27)
Several lines of evidence emphasize the potential function of G-quadruplex (G4) structures during DNA replication, transcription and recombination. Although there are experimental evidences that G4s play a role during ......
Effect of neural ablation of sphingosine-1-phosphate lyase (SGPL1) in glial cells
(2021-11-24)
Sphingosine-1-phosphate (S1P) is an evolutionarily conserved catabolic intermediate of sphingolipid metabolism that regulates diverse biological processes in the brain, including neural development, differentiation, and ...
Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
(2021-04-12)
The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ......
Structural and electronic decoupling of a large organic molecule from a metal surface by a single layer of hexagonal boron nitride
(2022-02-21)
In the present work, the ability of one single layer of hexagonal boron nitride (hBN) to decouple the organic molecule 3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA) from an underlying Cu(111) surface was investigated. ...
Das Dreistoffsystem Europium / Phosphor / Sauerstoff: Phasenbestand, Gleichgewichtsbeziehungen und Charakterisierung der Phosphate mit Ergänzungen zum Redoxverhalten von EuPO4 gegenüber Übergangsmetallen
(2021-08-17)
Das ternäre System Europium / Phosphor / Sauerstoff
Die Reihe der thermodynamisch stabilen, wasserfreien Europium(III)-phosphate erstreckt sich vom "basischen" Oxidphosphat EuIII ...
Die Reihe der thermodynamisch stabilen, wasserfreien Europium(III)-phosphate erstreckt sich vom "basischen" Oxidphosphat EuIII ...
Die Phyllosphäre als Lebensraum für Bakterien: Mechanismen der Interaktion epiphyller Bakterien mit der pflanzlichen Kutikula
(2020-12-16)
Die Phyllosphäre stellt einen lebensfeindlichen Lebensraum dar. Jedoch gibt es epiphytisch lebende Bakterien, die diesen Lebensumständen entgegenwirken und Mechanismen entwickelt haben, in diesem kargen Lebensraum Nährstoffe ......