E-Dissertationen: Search
Now showing items 11-20 of 40
Role of Endothelin-1 in the Brown Adipose Tissue
(2021-06-22)
ET-1 was shown to inhibit adipogenesis in murine mesenchymal stem cells derived from new-born brown adipose tissue in vitro and antagonism of Endothelin-1 (ET-1) signaling at the respective level of the Endothelin-1 receptor ...
The role of YAP signaling in thermogenic adiposetissues
(2021-01-02)
One of major metabolic organs, brown adipose tissue (BAT), is responsible for energy expenditure through uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis, which has been considered a promising pharmacological ...
Electrophysiological and pharmacological in vivo characterization of EEG fingerprints / biomarkers in AD mouse models
(2021-01-19)
Alzheimer’s disease (AD) is a major leading cause of deaths worldwide with underlying conditions of dementia and cognitive decline mostly in older age patients (≥ 65 years). Currently, there are approximately 50 million ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
The role of GPR111 in adipose tissue
(2021-05-21)
Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ......
Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance
(2021-03-18)
Cisplatin is a widely used drug in treatment of various solid tumors, amongst others ovarian cancer. However, whereas acquired resistance significantly limits therapy success, some tumors such as colorectal cancer are ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Histidine and Tyrosine-based Heme-binding Motifs for the Prediction of Heme-Regulated Proteins
(2021-06-01)
The versatile molecule heme (iron protoporphyrin IX) fulfils numerous vital functions as a part of hemoproteins, such as hemoglobin and cytochromes, in which it is essential for oxygen transport, electron transport, and ......
Histidin- und Tyrosin-basierte Hämbindemotive zur Vorhersage von Häm-regulierten Proteinen
Das vielseitige Molekül Häm (Eisenprotoporphyrin IX) erfüllt lebenswichtige Funktionen als Bestandteil ......
Histidin- und Tyrosin-basierte Hämbindemotive zur Vorhersage von Häm-regulierten Proteinen
Das vielseitige Molekül Häm (Eisenprotoporphyrin IX) erfüllt lebenswichtige Funktionen als Bestandteil ......
Bindung, Funktion und Signalwegbevorzugung von orthosterischen, allosterischen und Hybridliganden vermittelt durch Wildtyp und punktmutierte muskarinische hM1-hM5-Rezeptoren
(2021-12-16)
Bislang war ungeklärt, ob der Arzneistoff Methantheliniumbromid (MB) (Vagantin®) mit muskarinischen Acetylcholinrezeptoren (hM-Rezeptoren) interagiert (Teilprojekt 1). In umfassenden Untersuchungen konnte erstmalig ......
Low Endotoxin Recovery: Wiederfindung und pyrogene Aktivität von Endotoxinen in pharmazeutischen Produkten
(2021-08-06)
Eine zuverlässige Überwachung bakterieller Kontaminationen ist entscheidend für die Herstellung und Sicherheit biopharmazeutischer Produkte. Die mikrobielle Sicherheit wird in der Regel (zusätzlich zu Sterilitätstests und ...