E-Dissertationen: Suche
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Revealing the Mechanism of Thiopeptide Antibiotics at Atomistic Resolution: Implications for Rational Drug Design
(2012-07-18)
For decades drug design has primarily focused on small molecules that bind to well-formed tight binding pockets, such as the catalytic centers of enzymes. Recently, there is increasing interest to design compounds that ...
A Mathematical Model of the Potassium Homeostasis in Saccharomyces cerevisiae
(2012-07-20)
Without potassium, all living cells will die; it has to be present in sufficient amounts for the proper function of most cell types. Disturbances in potassium levels in animal cells result in potentially fatal conditions ...
Characterization of Parathyroid Hormone Receptor 1 in Periodontal Ligament Cells
(2012-07-13)
In addition to the classic catabolic effects, it is now widely accepted that parathyroid hormone (PTH) exerts anabolic effects on bone, when administered intermittently. As a result of the regenerative characteristic, ......
Mining the Medical and Patent Literature to Support Healthcare and Pharmacovigilance
(2012-07-18)
Recent advancements in healthcare practices and the increasing use of information technology in the medical domain has lead to the rapid generation of free-text data in forms of scientific articles, e-health records, ...
Characterization of the role of Hydroxyprostaglandin dehydrogenase 15-(NAD) in human regulatory T cells
(2012-06-14)
The focus of the present study was the characterization of the hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) in CD4+CD25+ regulatory T cells (Treg) concerning its regulation and role for the development and suppressive ...
Nemertean nervous system: a comparative analysis
(2012-07-13)
Most described nemerteans are marine benthic hunters. Thus, they possess a well developed nervous system. Basically, the nervous system comprises a four lobed brain, two main lateral medullary cords, some minor nerves, ...
Regulation of the dsr operon and function of the proteins DsrR and DsrS in the purple sulfur bacterium Allochromatium vinosum
(2012-05-25)
This work represents the first in depth investigation of the dsr gene expression in a phototrophic sulfur-oxidizing organism. Although over the last decade some observations were made concerning regulation a more detailed ...
Analyses of Adhesion Topography and Fluctuations in Bio-Membranes by Advanced Optical Microscopy
(2012-05-21)
The cell membrane not only mechanically separates the interior of the cell from the exterior environment but is also an active organelle involved in a host of functions like maintaining osmotic balance, aiding in ...
DNA barcoding & multi-isotopic fingerprinting: a novel forensic toolbox for the rapid identification of illegal trade in endangered wildlife species
(2012-05-08)
Over-exploitation through illegal wildlife trade is a major threat to a wide range of endangered mammal species around the world, particularly to the Felidae. Illegal trade in wild cats is often in the form of bones, meat, ...
Kontrolle der lateralen Organisation von Membranproteinen
(2012-06-12)
In den letzten Jahrzehnten wurde bei Untersuchungen an Zellmembranen deutlich, dass viele Membranproteine nicht, wie ursprünglich angenommen, homogen verteilt sind, sondern in Mikrodomänen organisiert vorkommen. Die ...