E-Dissertationen: Search
Now showing items 51-60 of 103
Molekulargenetische Untersuchungen bei uro-rektalen Fehlbildungen
(2014-02-07)
Zu den schwersten angeborenen uro-rektalen Fehlbildungen zählen der Blasenekstrophie-Epispadie-Komplex (BEEK) und anorektale Malformationen (ARM). BEEK wird klinisch hinsichtlich seines Schweregrades in drei verschiedene ......
The homeodomain of the Drosophila Ceramide Synthase Schlank confers nuclear import information and DNA binding capabilities
(2014-05-15)
Ceramide Synthases (CerS) are membrane bound enzymes at the center of the sphingolipid synthesis cascade. A sub-class of CerS also codes for a homeodomain of unknown function.
We previously identified the ...
We previously identified the ...
Einfluss der Johanniskrautinhaltsstoffe Hyperforin, Hyperosid und Hypericin auf die laterale Mobilität und die Signaltransduktion von 5-HT1A-Rezeptoren
(2014-05-02)
Johanniskrautextraktpräparate sind in Deutschland für die kurzzeitige Behandlung der Symptome leichter depressiver Störungen sowie für die Therapie von leichten bis mittelschweren Depressionen zugelassen. Die antidepressive ...
Molecular mechanisms underlying presynaptic plasticity: characterization of the RIM1α and SV2A interactome
(2015-02-11)
Synaptic plasticity encompasses various cellular mechanisms, which confer synapses the ability to react and adapt to ongoing changes in network activity. Some of the suggested mechanisms include remodelling and/or assembly ...
Evolution der Multiresistenz bei Escherichia coli
(2005)
Ziel der Arbeit war es, am Model E. coli Spuren zu finden, wie sich im Laufe der Evolution Multiresistenz entwickelt und wie die verantwortlichen Resistenzgene im Organismus organisiert sind. Resistenten oder sogar ...
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Analysis of human T lymphocyte-derived immune responses against Staphylococcus aureus by delivery of in vitro transcribed antigens
(2016-07-06)
Staphylococcus aureus is a harmless commensal of the human mucosa and at the same time the main cause of life-threatening nosocomial infections worldwide. In particular, the growing number of methicillin-resistant S. aureus ...
Molekulare Mechanismen TNF-vermittelter viraler Hepatitis
(2016-06-10)
Zytotoxische T-Lymphozyten (CTL) eliminieren selektiv Virus-infizierte Zellen, indem sie sie anhand von viralem Antigen erkennen, das auf deren Oberfläche präsentiert wird. Eine Ausnahme bildet eine kürzlich entdeckte ...
Selection of an aptamer and development of a genetic device to control mRNA stability in response to light
(2022-02-09)
Artificial autocatalytic RNA molecules, so-called aptazymes, are utilized as genetic devices to study and influence biological processes. These genetic devices consist of the autocatalytic RNA part, the ribozyme, and a ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...