E-Dissertationen: Search
Now showing items 141-150 of 255
Molekulare Mechanismen TNF-vermittelter viraler Hepatitis
(2016-06-10)
Zytotoxische T-Lymphozyten (CTL) eliminieren selektiv Virus-infizierte Zellen, indem sie sie anhand von viralem Antigen erkennen, das auf deren Oberfläche präsentiert wird. Eine Ausnahme bildet eine kürzlich entdeckte ...
New inhibitory pathways in CD8 T cell function
(2016-06-07)
An adaptive immune response is initiated upon recognition of antigen presented on the surface of antigen-presenting cell (APC) by T cells. CD8 T cells primed in the liver by antigen-presenting liver sinusoidal endothelial ......
Entwicklung und Evaluation eines Best-Practice-Modells zur Erhöhung der Arzneimitteltherapiesicherheit bei ambulanten Krebspatienten
(2016-05-17)
Die Kombination von Chemo- und Supportivtherapie und weiterer Therapien bei Komorbidität erhöht das Risiko für arzneimittelbezogenen Probleme. Ziel des Projektes war die Verbesserung der Arzneimitteltherapiesicherheit bei ...
The Control of Food Intake and Bitter Taste Information Processing in the Drosophila Larval Brain
(2016-12-22)
The regulation of feeding behavior by central neural circuits is crucial for every organism to survive. Hierarchical organized motor systems are responsible for the execution of appropriate feeding movements and can be ...
N-glycosylation of intrinsic and engineered N-X-S/T motifs by Pichia pastoris can be exploited to ligate the mannose receptor but reveals no gain in immunogenicity per se
(2016-12-22)
Vaccination has the power to eradicate viral diseases and is a promising approach to cure cancer. However, modern vaccination strategies repeatedly fail in inducing a robust cytotoxic CD8+ T cell response, which ...
Study on the role of Cofilin 2 in the brain
(2016-12-22)
Three actin depolymerization factors are expressed in the brain, named Cofilin 1 (non-muscle Cofilin), ADF and Cofilin 2, which was long declared as muscle-specific isoform. All three members share similar biochemical ...
Functional characterization of Cytoplasmic Polyadenylation Element Binding proteins in the developing and diseased brain
(2016-12-22)
Gliomas are the most common primary brain tumors with aggressive progression and devastating prognosis. Therefore identification of new therapeutic and diagnostic factors is necessary to improve the dramatic situation of ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Identification of protective immune responses and the immunomodulatory capacity of Litomosoides sigmodontis
(2016-11-29)
Using the mouse model Litomosoides sigmodontis, research focusing on the protective immune responses within the host as well as the immunomodulatory capabilities of filarial infections is possible. The immunomodulatory ......
Zelluläre und molekulare Mechanismen der Entzündungsauflösung im postoperativen Ileus
(2015-12-23)
Nach postoperativen Eingriffen kommt es regelhaft zu einer Darmmotilitätsstörung, dem sogenannte postoperativen Ileus (POI). Die Dauer und Intensität des POI werden von einer komplexen Entzündungsreaktion in der Muscularis ...