E-Dissertationen: Search
Now showing items 3941-3950 of 4104
Fluorescent proteins for two-photon FLIM analysis of presynaptic protein interactions
(2020-06-10)
Monitoring Förster Resonance Energy Transfer (FRET) between fluorescent proteins (FPs) fused to proteins of interest is a powerful approach to study dynamic interactions of cellular proteins in living cells. The choice of ...
Supersaturation and solubilization to enhance the oral bioavailability of poorly soluble drug molecules: A mechanistic understanding of their potential and limitations
(2021-07-28)
The stabilization of the supersaturated state in solution was in the last few decades identified as a suitable strategy to enhance the oral bioavailability of poorly soluble drug molecules. From this point of view, drug ...
Function of Cytoplasmic FMR1-interacting protein 2 (CYFIP2) in spinal motor neuron morphology during mouse embryonic development
(2022-06-03)
The development of the nervous system is a tightly regulated spatio-temporal process that involves actin cytoskeletal dynamics. The remodelling of the neuronal cytoskeleton is important for dendritic and axonal guidance, ...
The Genomic Loci Cer-za and Cer-ye Contribute to Cuticular Wax Biosynthesis in Hordeum vulgare
(2022-06-28)
Changing environmental conditions demand the expansion of the genetic resources to enable the rapid adaption and development of novel crop species. The cuticle as direct interface between plants and their environment is ......
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...
In vivo Relevant Drug Product Evaluation by Using the Biphasic Dissolution Assay (BiPHa+)
(2022-06-13)
An increasing number of new chemical entities struggled with a very poor solubility in aqueous media. Solubility or the ability to dissolve in intestinal media is obligatory for oral bioavailability. Dealing with this ......
Permissive and decisive roles of Hox code genes in limb induction
(2022-08-15)
Vertebrates display positional identities along the head-to-tail axis. The forelimb is one of the characteristics among them that shows its specific position at the interface between the cervical and thoracic region ...
Biodiversity and chemical ecology of selected gastropods from Iran, Persian Gulf
(2024-02-07)
Marine gastropods exhibit unique adaptations to marine environments have become a subject of interest in evolutionary biology. This study unveils Peronia persiae Maniei, Espeland, Mohavedi & Wägele, 2020, a new species of ......
Modulation der Expression und Funktion kardialer Gap Junction Kanäle
(2024-02-09)
Die elektrische Kopplung von Kardiomyozyten (KMs) im Herzen wird durch Connexine (Cx) vermittelt. Diese stellen durch die Bildung von Gap Junctions (GJs) Zell-Zell-Kontakte zwischen benachbarten KMs her. Im Herzmuskel ist ......
Targeted transport of active pharmaceutical ingredients into adipose tissue
(2023-02-21)
(noch nicht zugänglich / not yet accessible)