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Enzymatische Herstellung und Reinigung von Fructooligosacchariden des Inulin-Typs und deren Verwertung durch abundante Darmbakterien
(2024-01-24)
Fructooligosaccharide vom Inulin-Typ (I-FOS) sind präbiotische Fructan-Oligomere, die hauptsächlich aus ß-(2,1)-verknüpften Fructose-Einheiten bestehen. I-FOS haben aufgrund ihrer gesundheitsfördernden Wirkung und funktionellen ......
Benthic foraminifera as proxies to infer paleoenvironmental conditions: Case studies from Western Siberia, and the Arabian and Mediterranean Sea
(2024-01-22)
Foraminifera are among the most important microfossils and invaluable tools for geosciences. Because of their small size and abundance, foraminifera are widely involved in applied studies where they are used for age-dating, ...
Non-Reversible Markov-Chain Monte Carlo: Theoretical Foundations and Applications in Molecular Simulation
(2024-01-29)
The overarching objective of this doctoral thesis is the development of a rigorous paradigm for molecular simulation based on non-reversible Markov-chain Monte Carlo (MCMC) algorithms. The numerical exploration of the ......
Das Cyclodepsipeptid FR900359: Ein Insektizid mit neuem Wirkmechanismus aus Cand. Burkholderia crenata und Chromobacterium vaccinii
(2024-01-16)
Sekundärmetabolite (SM) sind für ihr breites Spektrum an Bioaktivitäten bekannt und daher eine wichtige Quelle für neue Arzneimittelkandidaten. Neben ihrer Relevanz für die Therapie von Erkrankungen sind SM und ihre ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
Pulsar Scintillation and Interstellar Lenses
(2024-01-29)
The radio emission of pulsars is scattered within the interstellar medium due to variations of the electron column density. Pulsars are very compact sources of pulsed radiation and, thus, emit spatially coherent radiation ...
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ...
Characterizing Time-Evolving Functional Networks
(2024-01-10)
Understanding spatially-extended, complex dynamical systems is a vital task in the natural sciences. From the climate over eco-socio-cultural systems to the human brain, time-evolving complex systems abound. These systems ...
Optogenetic investigation of local adrenaline signaling effects on cardiac arrhythmia mechanisms
(2024-01-15)
Ventricular arrhythmias are one of the major causes of death worldwide, occurring especially in structurally remodeled hearts, but also in hereditary conditions, such as CPVT, in which mutations in RyR2 or Casq2 cause ...
Cilia-dependent signaling pathways controlling adipose tissue plasticity
(2022-11-15)
Primary cilia serve as cellular antennae that detect extracellular signals and transduce this information into an intracellular response. Dysfunction of primary cilia leads to a range of severe diseases, i.e., the ......
Primäre Zilien dienen als zelluläre Antenne, welche extrazelluläre Signale detektieren und eine zelluläre Reaktion hervorrufen. Dysfunktionale primäre Zilien rufen eine Reihe an schwerwiegenden Erkrankungen hervor, wie das ......
Primäre Zilien dienen als zelluläre Antenne, welche extrazelluläre Signale detektieren und eine zelluläre Reaktion hervorrufen. Dysfunktionale primäre Zilien rufen eine Reihe an schwerwiegenden Erkrankungen hervor, wie das ......
Impact of Plant Secondary Metabolites on the Soil Microbiota
(2022-08-26)
This study revealed the impact of 2-benzoxazolinone (BOA), gramine, and quercetin on the microbiota in the bulk soil (Cologne agricultural soil) and investigated direct interactions of the plant secondary metabolites and ...