E-Dissertationen: Search
Now showing items 3961-3970 of 4112
Pulsar Scintillation and Interstellar Lenses
(2024-01-29)
The radio emission of pulsars is scattered within the interstellar medium due to variations of the electron column density. Pulsars are very compact sources of pulsed radiation and, thus, emit spatially coherent radiation ...
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ...
Characterizing Time-Evolving Functional Networks
(2024-01-10)
Understanding spatially-extended, complex dynamical systems is a vital task in the natural sciences. From the climate over eco-socio-cultural systems to the human brain, time-evolving complex systems abound. These systems ...
Optogenetic investigation of local adrenaline signaling effects on cardiac arrhythmia mechanisms
(2024-01-15)
Ventricular arrhythmias are one of the major causes of death worldwide, occurring especially in structurally remodeled hearts, but also in hereditary conditions, such as CPVT, in which mutations in RyR2 or Casq2 cause ...
Cilia-dependent signaling pathways controlling adipose tissue plasticity
(2022-11-15)
Primary cilia serve as cellular antennae that detect extracellular signals and transduce this information into an intracellular response. Dysfunction of primary cilia leads to a range of severe diseases, i.e., the ......
Primäre Zilien dienen als zelluläre Antenne, welche extrazelluläre Signale detektieren und eine zelluläre Reaktion hervorrufen. Dysfunktionale primäre Zilien rufen eine Reihe an schwerwiegenden Erkrankungen hervor, wie das ......
Primäre Zilien dienen als zelluläre Antenne, welche extrazelluläre Signale detektieren und eine zelluläre Reaktion hervorrufen. Dysfunktionale primäre Zilien rufen eine Reihe an schwerwiegenden Erkrankungen hervor, wie das ......
Impact of Plant Secondary Metabolites on the Soil Microbiota
(2022-08-26)
This study revealed the impact of 2-benzoxazolinone (BOA), gramine, and quercetin on the microbiota in the bulk soil (Cologne agricultural soil) and investigated direct interactions of the plant secondary metabolites and ...
Danger signaling pathways in aortic disease
(2024-02-19)
The aorta connects the heart to the peripheral circulation and organs. It is necessary for the regulation of hemodynamics and therefore, aortic disease affects all organs and the survival of the individual. In aortic valve ...
Wozu Region?: Regionalisierungen als projekthaftes Organisationsgeschehen - systemtheoretisch rekonstruiert am Beispiel der Energiewende
(2022-12-23)
Die Dissertation von Claudia Kölsche mit dem Titel „Wozu Region? Regionalisierungen als projekthaftes Organisationsgeschehen – systemtheoretisch rekonstruiert am Beispiel der Energiewende“ beginnt mit der Beobachtung, dass ...
Optogenetische Stimulation des nativen Herzmuskels durch Adeno-assoziierte Virustransduktion von Channelrhodopsin-2
(2022-12-15)
Die Optogenetik ist eine innovative Methode, die die transgene Expression von lichtsensitiven Proteinen verwendet zur elektrophysiologischen oder biochemischen Stimulation von Zellen durch Beleuchtung. Das Beleuchten mit ......
Towards a better understanding of neuron-NG2 glia signaling: Comparative studies in the hippocampus and cerebellum
(2024-02-01)
Grey matter NG2 glia constitutes a heterogeneous glial population whose functions remain incompletely understood. Their ability to make synapses with neurons is unique among glial cells, but the purpose of these connections ...