E-Dissertationen: Suche
Anzeige der Dokumente 1-2 von 2
Investigation of Quinazoline Derivatives as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)
(2018-03-12)
The treatment of cancer with chemotherapeutic drugs is strongly limited by intrinsic or aquired resistance of the cancer cells. This is the main reason of a failure of the therapy. The cellular resistance mostly originates ...
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...