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Role of innate lymphoid cells in type 1-dominated experimental Plasmodium berghei ANKA and type 2-dominated Litomosoides sigmodontis infection
(2021-10-27)
Malaria and filariasis remain among the biggest health problems in the tropics and subtropics, especially in Africa, and in the case of malaria among the ten most frequent causes of death. The parasites that cause malaria ......
Filarial nematodes protect against malaria in a murine co-infection model
(2008)
Helminth infections such as filariasis can be life long due to immunomodulatory mechanisms elicited by the worms that prevent their elimination by the human host. Malaria prevalence is frequently high in areas where ...
Filarial infection and filarial antigen administration promotes glucose tolerance in diet-induced obese mice
(2015-11-06)
Excess of energy intake combined with reduced physical activity leads to accumulation and expansion of adipose tissue. Imbalance between adipose tissue expansion and oxygenation during a high fat diet results in adipocytes ...
Eosinophil Extracellular DNA Trap Cell Death (EETosis) occurs as a life-cycle stage-specific response to filariae
(2020-06-25)
Filarial nematodes represent a great burden of human morbidity causing diseases like onchocerciasis and lymphatic filariasis. The lack of a vaccination and a short-term therapy with a macrofilaricidal effect hampers the ......
Acetylcholine mediates protective immune responses against the rodent filarial nematode Litomosoides sigmodontis
(2022-02-22)
Tropical infectious diseases are caused by parasitic helminths, such as lymphatic filariasis and onchocerciasis (river blindness). Filariae have the ability to modulate the immune response of their host in order to be ......
Pattern Recognition Receptor and Vaccination Studies in the Murine Model of Lymphatic Filariasis
(2013-03-06)
Lymphatic filariasis is a parasitic helminth infection that affects approximately 120 million people. About one third of the infected individuals develop pathological manifestations, e.g. lymphedema. Causative agents of ......
Concepts of Immune Regulation in Chronic Filarial Infections
(2021-04-21)
Despite worldwide efforts to reduce filariasis, over 100 million individuals still suffer from filarial infections. Filarial infections continue to be a substantial drain at both economic and health levels, especially in ......
Characterization of the immune system-drug interactions during anti-filarial treatment in the Litomosoides sigmodontis mouse model
(2024-01-03)
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Both diseases are included in the list of neglected tropical diseases as defined by the World Health Organization (WHO) ......