E-Dissertationen: Suche
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Consequence of FA2H Deficiency and FA2H Interaction Partners Revealed by Proteomic Analyses
(2015-03-10)
Fatty acid-2 hydroxylase (FA2H) is a 43 kDa transmembrane protein residing in the endoplasmic reticulum. As a monooxygenase it is responsible for the alpha–hydroxylation of fatty acids, which are later incorporated into ...
Untersuchung der molekularen Funktion des Stammzellfaktors Trim71 in der Karzinogenese
(2015-07-28)
Trim71 ist ein hoch konserviertes Gen, das in Vertebraten und Invertebraten als Regulator der Embryonalentwicklung entdeckt wurde. Außerdem konnten neuere Studien zeigen, dass Trim71 eine wichtige Rolle in der Kontrolle ...
Characterization of panglial gap junction networks in the thalamus and hippocampus reveals glial heterogeneity
(2015-05-27)
Increasing evidence over the past decades revealed the importance of glia in the brain. In this study, astrocytes in the ventrobasal thalamus were characterized in detail for the first time. Glial heterogeneity was ...
The cannabinoid receptor 2: from mouse to human
(2015-05-13)
The endocannabinoid system (ECS) regulates numerous cellular and physiological processes. Nowadays, the system comprises two G protein-coupled receptors named CB1 and CB2 receptor, and the endogenous ligands anandamide ......
Geostatistical Analysis of Genetic Diversity in the Present Male Argentine Population
(2015-08-03)
The geographical study of genetic diversity has a long history in fields related to population genetics. Its relevance has been already acknowledged in the 1940's and numerous tools have been developed since then. Most of ...
RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
Genetics of schizophrenia: Contribution of rare and low-frequency sequence variants in selected genomic regions to disease susceptibility
(2015-03-27)
Schizophrenia is a highly heritable, multifactorial mental disorder. Up to date, a number of common SNPs with low penetrance and large rare structural variants (CNVs) with higher penetrance have been identified to contribute ......
Biochemische, strukturelle und kinetische Charakterisierung des ungewöhnlichen c-Typ Cytochroms Thiosulfatdehydrogenase
(2015-02-24)
Thiosulfatdehydrogenasen sind Dihäm c-Typ Cytochrome mit einer ungewöhnlichen His/Cys-Koordination eines Hämes und weit verbreitet unter Bakterien. TsdA-Proteine kommen in allen Gruppen der Proteobakterien und auch in ......
Optogenetische Kontrolle von cAMP durch eine photoaktivierte Adenylatzyklase
(2015-03-27)
Optogenetik ist eine Methode, bei der lichtaktivierbare Proteine zur Manipulation zellulärer Funktionen verwendet werden. Häufig genutzt werden hierbei lichtaktivierbare Ionenkanäle und -pumpen, wie beispielsweise ......
Rearranged DNA in mitochondrial DNA maintenance disorders
(2015-03-31)
Mitochondrial genetics has been changing its focus during the last decade. Originally limited to describing effects of mutations of the mitochondrial DNA (mtDNA) research at present aims to understand circumstances of ...