E-Dissertationen: Search
Now showing items 1-10 of 19
The Parkinson’s disease-related kinase Pink1 mediates mitochondrial quality control
(2016-08-29)
Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, in particular Parkinson’s disease (PD). Mutations in the genes encoding the mitochondrial kinase Pink1 and the cytosolic E3 ubiquitin ligase ...
Biosynthesis of soluble capsule precursors in Staphylococcus aureus
(2016-11-28)
Most invasive pathogens produce polysaccharide capsules, which play an essential role in conferring protection against host immune defense. In the case of Staphylococcus aureus, most clinical isolates are encapsulated, and ......
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Analysis of human T lymphocyte-derived immune responses against Staphylococcus aureus by delivery of in vitro transcribed antigens
(2016-07-06)
Staphylococcus aureus is a harmless commensal of the human mucosa and at the same time the main cause of life-threatening nosocomial infections worldwide. In particular, the growing number of methicillin-resistant S. aureus ...
Der Einfluss physiologischer Sauerstoffkonzentrationen auf natürliche Killerzellen bei der Hepatitis C Virus- und der Humanes Immundefizienzvirus-Infektion
(2016-07-21)
Natürliche Killerzellen (NK-Zellen) spielen als wichtiger Bestandteil des innaten Immunsystems eine zentrale Rolle bei Viruserkrankungen, so auch der Hepatitis C Virus (HCV)- und der Humanes Immundefizienzvirus (HIV)-Infektion. ...
Molekulare Mechanismen TNF-vermittelter viraler Hepatitis
(2016-06-10)
Zytotoxische T-Lymphozyten (CTL) eliminieren selektiv Virus-infizierte Zellen, indem sie sie anhand von viralem Antigen erkennen, das auf deren Oberfläche präsentiert wird. Eine Ausnahme bildet eine kürzlich entdeckte ...
New inhibitory pathways in CD8 T cell function
(2016-06-07)
An adaptive immune response is initiated upon recognition of antigen presented on the surface of antigen-presenting cell (APC) by T cells. CD8 T cells primed in the liver by antigen-presenting liver sinusoidal endothelial ......
The Control of Food Intake and Bitter Taste Information Processing in the Drosophila Larval Brain
(2016-12-22)
The regulation of feeding behavior by central neural circuits is crucial for every organism to survive. Hierarchical organized motor systems are responsible for the execution of appropriate feeding movements and can be ...
N-glycosylation of intrinsic and engineered N-X-S/T motifs by Pichia pastoris can be exploited to ligate the mannose receptor but reveals no gain in immunogenicity per se
(2016-12-22)
Vaccination has the power to eradicate viral diseases and is a promising approach to cure cancer. However, modern vaccination strategies repeatedly fail in inducing a robust cytotoxic CD8+ T cell response, which ...
Study on the role of Cofilin 2 in the brain
(2016-12-22)
Three actin depolymerization factors are expressed in the brain, named Cofilin 1 (non-muscle Cofilin), ADF and Cofilin 2, which was long declared as muscle-specific isoform. All three members share similar biochemical ...