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Complement-mediated neuronal loss by sialic acid glycocalyx alterations
(2018-04-23)
Every neuronal cell is covered with a dense structure of glycoconjugates, the glycocalyx. Sialic acids form the terminal ends of the glycocalyx and thus, are more accessible for the cellular environment. Microglia, the ...
Ectopic expression of the sialic acid modifying enzyme CMAH in human THP1 macrophages
(2018-09-03)
Throughout evolutionary processes, organisms gain or lose functions because of emerging mutations. The frameshift mutation emerged in the human CMAH gene is one of these loss of function mutations and it caused the human ...