E-Dissertationen: Search
Now showing items 1-6 of 6
Identifizierung und Charakterisierung eines neuen Inhibitors der PH-Domäne der Cytohesin-Familie
(2011-07-04)
Die Pleckstrin-homologe Domäne (PH-Domäne), die in vielen Proteinen zu finden ist, ist durch ihre Interaktion mit Phosphoinositiden (z.B. PIP3) entscheidend an der Membranrekrutierung dieser Proteine beteiligt.
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RNA aptamers as selective protein kinase inhibitors: New molecular tools for the elucidation of signal transduction pathways
(2015-04-16)
Elucidating the precise function of individual protein kinases within complex signal transduction cascades represents one of the greatest challenges in molecular biology. Protein kinases are enzymes that catalyze the ...
Synthesis and Characterisation of wALAD Inhibitors and Novel ABAL Probes
(2016-10-12)
The here presented work comprises two projects with highly interdisciplinary topics in the chemical biology field. The development of novel small molecule ALAD inhibitors which might show their potential as novel antifilarial, ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...
Functional Modulation of Activated Protein C using DNA-Aptamers
(2017-03-15)
Aptamers are single stranded DNA or RNA oligonucleotides which are able to interact with their designated target molecules with high affinity and specificity. The in-vitro procedure used for aptamer selection from a randomly ...
Click-SELEX enables the selection of Δ9-tetrahydrocannabinol-binding nucleic acids
(2019-05-10)
Δ9-Tetrahydrocannabinol (THC) is the main psychoactive compound in the plant Cannabis sativa and the most widely used illegal drug in the world. Its consumption impairs driving skills such as keeping a vehicle on track and ...