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Improving solubility and supersaturation of poorly soluble drugs using solid dispersions based on natural polymers and mixtures thereof
(2021-05-19)
The poor solubility of existing drug substances and new chemical entities is a problem in modern pharmaceutical development. There are various strategies to overcome the solubility limited bioavailability of poorly soluble ...
Particle engineering for high dose dry powder inhalation of itraconazole
(2022-12-05)
Itraconazole (ITZ) is considered as first-line therapy against respiratory infections such as allergic bronchopulmonary aspergillosis. Local treatment of these infections is regarded beneficial as it might reduce systemic ...
Vacuum drum drying: a novel technology for enabling formulation principles in the development of oral solid dosage forms
(2022-11-21)
The present work demonstrates the applicability of vacuum drum drying (VDD) as novel technology in the development of solid, oral dosage forms for two enabling formulation principles: a) manufacture of amorphous solid ...