E-Dissertationen: Search
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Investigations on the early biosynthetic steps of griseorhodin A
(2012-05-03)
Presented here are the results concerning the early biosynthesis of the telomerase inhibitor griseorhodin A.
The griseorhodin biosynthetic gene cluster encodes components of a type II polyketide synthase (PKS). The ......
The griseorhodin biosynthetic gene cluster encodes components of a type II polyketide synthase (PKS). The ......
Revealing the Mechanism of Thiopeptide Antibiotics at Atomistic Resolution: Implications for Rational Drug Design
(2012-07-18)
For decades drug design has primarily focused on small molecules that bind to well-formed tight binding pockets, such as the catalytic centers of enzymes. Recently, there is increasing interest to design compounds that ...
Analyses of Adhesion Topography and Fluctuations in Bio-Membranes by Advanced Optical Microscopy
(2012-05-21)
The cell membrane not only mechanically separates the interior of the cell from the exterior environment but is also an active organelle involved in a host of functions like maintaining osmotic balance, aiding in ...