E-Dissertationen: Suche
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Aptamerselektion zur Funktionsuntersuchung von zytosolischen Proteinen
(2007)
Zur biologischen Einordnung der CC-bindenden Proteine CYTIP und KIAA0403 einem auf Genomebene neu entdeckten Vertreter, wie auch FHL2, einem vielseitigen Ko-Transkriptionsfaktor, wurde die Aptamertechnologie zur in vitro ...
Simultaneous identification of nucleotide-modified aptamers with different properties by multiplexed click-SELEX
(2020-06-18)
Voltage-gated sodium channels (VGSC) are important key regulators in excitable tissue that initiate and propagate the action potential in specifically excitable tissue such as brain nerves or muscle. In order to understand ...
Synthesis and Characterisation of wALAD Inhibitors and Novel ABAL Probes
(2016-10-12)
The here presented work comprises two projects with highly interdisciplinary topics in the chemical biology field. The development of novel small molecule ALAD inhibitors which might show their potential as novel antifilarial, ...
Click-SELEX: A versatile approach towards nucleobase-modified aptamers
(2016-11-28)
Aptamers are short nucleic acids that can be selected to bind specifically and with high affinity to a variety of targets, including small organic molecules and proteins. However, for a multitude of targets, traditional ...