E-Dissertationen: Search
Now showing items 1-7 of 7
In Silico Facets of Biochemical Research: Accounts from Protein Folding and Protein-Ligand Interaction Studies
(2020-09-04)
Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ......
Migration of interneuronal precursor cells in the developing cerebellum of mice: model-based cell tracking and simulation
(2010-12-10)
The navigation of precursor cells of inhibitory interneurons from their germinal zone inside the fourth ventricle through the white matter towards their final destination within the cerebellum's molecular layer is an ongoing ...
New bioactive metabolites from the marine-derived fungus Dichotomomyces cejpii and their pharmacological relevance
(2015-01-13)
Natural products from fungal sources provide an astonishing diversity of bioactive molecules. The secondary metabolite production in fungi is strongly affected by environmental influences and the isolation of fungal strains ......
Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation
(2015-01-16)
Sialic acid binding Siglecs are involved in various pathological processes. A minor fraction of Siglecs mediates activating signals via the ITAM linked DAP12 adaptor protein while the majority of Siglecs modulates inflammatory ......
Evolution of the Activity Cliff Concept and Practical Implications for Compound Design
(2021-07-22)
Entering the “big data” era, a number of different research areas have witnessed an enormous increase in data at an exponential rate. For drug discovery, various publicly available protein structure and compound bioactivity ...
Predicting Rules for Cancer Subtype Classification using Grammar-Based Genetic Programming on various Genomic Data Types
(2018-03-12)
With the advent of high-throughput methods more genomic data then ever has been generated during the past decade. As these technologies remain cost intensive and not worthwhile for every research group, databases, such as ...
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)