E-Dissertationen: Search
Now showing items 1-5 of 5
The implication of microglial sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) in neuroinflammation
(2014-03-07)
Microglia are the resident immune cells of the central nervous system (CNS). They display a whole set of recognition receptors on their cell surface to sense intact or lesioned cells in the CNS. A subfamily of these receptors ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Transmission of pathogenic α-synuclein to mice
(2017-09-01)
α-Synuclein is a soluble, cellular protein that in a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy, and Lewy body dementia aggregates into pathological protein deposits. ...
Toward a precision medicine in Alzheimer’s Disease: blood phenomic fingerprint for diagnostic and therapeutic developments
(2020-05-05)
There is an unmet clinical need to identify reliable blood biomarkers for Alzheimer’s Disease (AD) that can be used for diagnostics and therapeutic purposes.
The complex nature of AD, single-readout approaches ......
The complex nature of AD, single-readout approaches ......
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
(2018-12-12)
When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ...