E-Dissertationen: Search
Now showing items 1-6 of 6
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
Mechanism-based Stratification of Alzheimer's and Parkinson's Disease using Artificial Intelligence
(2021-03-29)
The capacity to generate omics and clinical data in biomedical science is growing exponentially over the past decades. Additionally, recent advances in computational power and analyzing capabilities have resulted in ...
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
(2022-08-01)
Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ...
AI Models for Modeling and Simulation of Clinical Studies for Alzheimer's and Parkinson's Disease
(2023-08-14)
Neurodegenerative diseases (NDDs) have a complex structure and most of them are untreatable that’s why more research studies undertake translational paths for getting better insights into prevention, early detection, and ...
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ...