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Synaptic vesicle protein 2A (SV2A) and connexin 43 (Cx43) as targets for epilepsy: establishment of assays and identification of ligands
Epilepsy is a chronic neurological disorder affecting around 1% of the human population worldwide. The antiepileptic drugs (AEDs) available on the market provide symptomatic relief from epilepsy but do not cure the disease. ...
Hippocampal cellular and network properties in a mouse model of metachromatic leukodystrophy
The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...