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RIMs and RIM interacting proteins: localization and function under physiological and pathophysiological conditions
Neurons transmit signals to their target cells at specialized contact sites called synapses. At chemical synapses the signal propagation is mediated by the fusion of neurotransmitter filled synaptic vesicles with the ...
Copy number variations of the mitochondrial DNA as potential cause of mitochondrial diseases
Aim: The aim of this thesis was the analysis of copy number variations of the mitochondrial DNA (mtDNA) in several tissues and cell types with regard to different mitochondrial associated disorders.<br /> Background: The ...
The contribution of the sodium channel subunit Na<sub>V</sub>1.6 to neuronal excitability
The focus of this work was to elucidate the contribution of a single Na<sup>+</sup> channel a-subunit, namely Na<sub>V</sub>1.6, to the discharge properties of CA1 pyramidal neurons. In the first part of this work, we show ...
Mechanisms of memory consolidation: Analyzing the coordinated activity of concept neurons in the human medial temporal lobe during waking and sleep
The aim of this thesis is to investigate the role of human concept neurons in memory consolidation during sleep. Memory consolidation is a process by which memories initially dependent on the hippocampus are transferred ...
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Hippocampal cellular and network properties in a mouse model of metachromatic leukodystrophy
The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...