E-Dissertationen: Search
Now showing items 1-10 of 12
Copy number variations of the mitochondrial DNA as potential cause of mitochondrial diseases
(2010-12-30)
Aim: The aim of this thesis was the analysis of copy number variations of the mitochondrial DNA (mtDNA) in several tissues and cell types with regard to different mitochondrial associated disorders.
Background: The ...
Background: The ...
Charakterisierung der Stärke und Richtung von Interaktionen zwischen dynamischen Systemen mit Zellularen Neuronalen Netzen
(2010-09-01)
In der vorliegenden Dissertation werden Stärke und Richtung von Interaktionen zwischen komplexen dynamischen Systemen mit Zellularen Neuronalen Netzen (CNN) erfolgreich charakterisiert. Die Berechnung von Kenngrößen zur ...
Symbolische Transferentropie: Charakterisierung gerichteter Interaktionen in nichtlinearen dynamischen Netzwerken
(2011-01-11)
Im Rahmen der vorliegenden Arbeit wird untersucht, inwiefern eine Charakterisierung der Kopplungsrichtung zwischen komplexen dynamischen Systemen mit einer auf Konzepten der nichtlinearen Dynamik, der Informationstheorie ...
The contribution of the sodium channel subunit NaV1.6 to neuronal excitability
(2010-04-13)
The focus of this work was to elucidate the contribution of a single Na+ channel a-subunit, namely NaV1.6, to the discharge properties of CA1 pyramidal neurons. In the first part of this work, we show ...
Hippocampal cellular and network properties in a mouse model of metachromatic leukodystrophy
(2017-11-30)
The human disease of metachromatic leukodystrophy (MLD) is caused by a single or multiple allelic mutations within the gene locus of arylsulfatase A (ASA). This protein is a lysosomal enzyme catalyzing the degradation of ...
Synaptic vesicle protein 2A (SV2A) and connexin 43 (Cx43) as targets for epilepsy: establishment of assays and identification of ligands
(2017-09-12)
Epilepsy is a chronic neurological disorder affecting around 1% of the human population worldwide. The antiepileptic drugs (AEDs) available on the market provide symptomatic relief from epilepsy but do not cure the disease. ...
Reconstructing Human Motion
(2018-05-22)
This thesis presents methods for reconstructing human motion in a variety of applications and begins with an introduction to the general motion capture hardware and processing pipeline.
Then, a data-driven method for ...
Then, a data-driven method for ...
Mechanisms of memory consolidation: Analyzing the coordinated activity of concept neurons in the human medial temporal lobe during waking and sleep
(2018-12-11)
The aim of this thesis is to investigate the role of human concept neurons in memory consolidation during sleep. Memory consolidation is a process by which memories initially dependent on the hippocampus are transferred ...
Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus
(2019-05-21)
Globally, at least 50 million people suffer from epilepsy and almost one third of these do not respond to treatment with one or even multiple antiepileptic drugs (AEDs). One of the most prominent approaches trying to explain ...
Komplexe dynamische Systeme als funktionelle Netzwerke: Möglichkeiten und Grenzen der datengetriebenen Analyse
(2012-03-12)
Aus einer Vielzahl von Subsystemen zusammengesetzte dynamische Systeme können als Netzwerk aufgefasst und mit Methoden der Graphentheorie beschrieben werden. Innerhalb dieses Ansatzes werden die Subsysteme durch Knoten und ...
