E-Dissertationen: Suche
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Pharmakokinetische/pharmakodynamische Ansätze zur Dosisoptimierung antitumoraler Metallkomplexe
(2011-03-08)
Metallkomplexe sind seit langem ein essentieller Bestandteil einer Vielzahl von Chemotherapieregimen. Doch gerade die Dosierung von Zytostatika ist eine Gradwanderung zwischen dem Erreichen des bestmöglichen Effekts und ...
Pharmacokinetic / Pharmacodynamic Modeling and Simulation of Biomarker Response to Venlafaxine and Sunitinib Administration
(2011-03-23)
In this thesis the concept of pharmacokinetic/pharmacodynamic modeling using biomarkers for the description of concentration-effect relationships was illustrated on the example of two projects with drugs from different ...
Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
(2019-07-22)
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...