E-Dissertationen: Search
Now showing items 1-10 of 28
Identification of Genomic Alterations in Castration Resistant Prostate Cancer using Next Generation Sequencing
(2014-01-03)
Castration resistant prostate cancer (CRPC) is the most aggressive form of prostate cancer (PCa). For the development of novel therapeutic targets for CRPC, it is key to decipher the molecular alterations underlying this ......
Medizinische Chemie G-Protein-gekoppelter P2Y- und verwandter Waisen-Rezeptoren: Synthese, Optimierung und Charakterisierung selektiver Liganden als pharmakologische Tools
(2014-07-01)
G-Protein-gekoppelte Rezeptoren (GPCRs) weisen eine große therapeutische Relevanz auf. Unter ihnen existieren auch sogenannte Waisen-Rezeptoren, deren endogener Ligand noch unbekannt ist. Im Hinblick auf die Entwicklung ...
Systemic Administration of Epothilone B Promotes Axon Regeneration and Functional Recovery after Spinal Cord Injury
(2014-07-07)
After central nervous system (CNS) injury, such as a traumatic spinal cord injury (SCI), damaged axons fail to regenerate resulting in a permanent loss of sensorimotor functions. Regeneration is prevented by growth inhibitory ...
Entkopplung von Astrozyten als Ursache von Temporallappenepilepsie: Funktionelle Analysen im Tiermodell
(2014-07-03)
Astrozyten sind der häufigste Zelltyp im menschlichen Gehirn. Die ursprüngliche Sichtweise, dass die Astrozyten nur als eine Art Kitt für die Neurone dienen, ist seit mehreren Jahren widerlegt. Zahlreiche Versuche zeigen, ...
The role of linear energy transfer in modulating radiationinduced NF-κB activation and its down-stream target genes
(2014-07-23)
To enable long-term human spaceflight, the cellular radiation response to heavy ions with a high linear energy transfer (LET) needs to be better understood for developing appropriate countermeasures to mitigate acute effects ...
Neurotransmitter receptors in mouse models of Alzheimer’s disease
(2014-06-20)
Alzheimer's disease (AD) is the most common form of dementia. The disease occurs in a common sporadic and a familiar form (FAD). Both forms show a very similar clinical and pathological picture, with ß-amyloid (Aß) plaques ...
The Mannose receptor induces T cell tolerance via inhibition of CD45 and up-regulation of CTLA-4
(2014-03-28)
The present study proves that the mannose receptor (MR) bears beside its function as endocytic receptor a second responsibility namely the induction of tolerance.
The results of our experiments show that the decision, ......
The results of our experiments show that the decision, ......
Molekulargenetische Untersuchungen bei uro-rektalen Fehlbildungen
(2014-02-07)
Zu den schwersten angeborenen uro-rektalen Fehlbildungen zählen der Blasenekstrophie-Epispadie-Komplex (BEEK) und anorektale Malformationen (ARM). BEEK wird klinisch hinsichtlich seines Schweregrades in drei verschiedene ......
The implication of microglial sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) in neuroinflammation
(2014-03-07)
Microglia are the resident immune cells of the central nervous system (CNS). They display a whole set of recognition receptors on their cell surface to sense intact or lesioned cells in the CNS. A subfamily of these receptors ...
Determining the Role of Sonic Hedgehog in Establishing Midbrain Dopaminergic Neuron Subclasses
(2014-02-21)
Midbrain dopaminergic neurons (MbDNs) in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc) modulate cognition, reward behavior and voluntary movement, respectively. Recent findings indicate that ...