E-Dissertationen: Search
Now showing items 1-10 of 25
Identifying intracellular cisplatin interaction partners and assessing their contribution to cisplatin resistance
(2016-10-24)
Intracellular binding of cisplatin to non-DNA partners, such as proteins, has received increasing attention as an additional mode of action as well as a mechanism of resistance. In this project three cisplatin-interacting ...
Chelation as a strategy with the potential to overcome multidrug resistance in cancer
(2016-09-02)
According to the World Health Organisation cancer is the second leading cause of death in industrialized countries. In many cases treatment fails due to the development of resistance against multiple (structurally and ...
Structural and functional characterization of G protein-coupled adenosine receptors and the orphan receptor GPR143
(2016-05-24)
The present thesis deals with the characterization of G protein-coupled receptors (GPCRs) and their interaction with modulators on a molecular level. We focused on the structural and functional investigation of different ...
Analysis of human T lymphocyte-derived immune responses against Staphylococcus aureus by delivery of in vitro transcribed antigens
(2016-07-06)
Staphylococcus aureus is a harmless commensal of the human mucosa and at the same time the main cause of life-threatening nosocomial infections worldwide. In particular, the growing number of methicillin-resistant S. aureus ...
Biosynthese und Analytik von Sesquiterpenen in Weinbeeren (Vitis vinifera)
(2016-05-17)
Mit dem Sesquiterpen Rotundon wurde 2008 erstmals ein Sesquiterpen als Schlüsselaromastoff im Wein identifiziert. Bis dato lagen nur wenige Informationen zu Sesquiterpenen in Vitis vinifera vor. Ziel dieser Arbeit war es ......
Steep, Spatially Graded Recruitment of Feedback Inhibition by Sparse Dentate Granule Cell Activity
(2016-05-24)
The dentate gyrus of the hippocampus is thought to subserve important physiological functions, such as 'pattern separation'. In chronic temporal lobe epilepsy, the dentate gyrus constitutes a strong inhibitory gate for the ...
Molekulare Mechanismen TNF-vermittelter viraler Hepatitis
(2016-06-10)
Zytotoxische T-Lymphozyten (CTL) eliminieren selektiv Virus-infizierte Zellen, indem sie sie anhand von viralem Antigen erkennen, das auf deren Oberfläche präsentiert wird. Eine Ausnahme bildet eine kürzlich entdeckte ...
Fog Collection on Plant Surfaces and Biomimetic Applications
(2016-06-23)
Shortages of fresh water affect around one billion people world-wide; mostly in arid and semi-arid climates. Fog, in certain regions, may be an important source of water that is often overlooked. Inspired by the distinctive ...
3D-Modeling of unsaturated flow dynamics and pattern: Potentials and Limitations at different spatial and temporal scales
(2016-06-14)
The aim of this thesis was to evaluate the suitability of the physically based, distributed 3D hydrological model HydroGeoSphere for the simulation of spatio-temporal soil moisture variability as well as unsaturated flow ...
Der Einfluss einer chronischen Koffeinapplikation auf das adenosinerge System im Hinblick auf schlafregulierende und neuroprotektive Effekte im ZNS der Ratte
(2016-06-23)
Auf molekularer Ebene stellt Adenosin nach bisheriger Kenntnis die bedeutendste, endogen schlaffördernde Substanz dar. Es akkumuliert nach verlängerten Wachphasen und induziert auf diese Weise den Einschlafprozess, um mit ...