E-Dissertationen: Search
Now showing items 1-7 of 7
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
Modulation der Expression und Funktion kardialer Gap Junction Kanäle
(2024-02-09)
Die elektrische Kopplung von Kardiomyozyten (KMs) im Herzen wird durch Connexine (Cx) vermittelt. Diese stellen durch die Bildung von Gap Junctions (GJs) Zell-Zell-Kontakte zwischen benachbarten KMs her. Im Herzmuskel ist ......
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ...
Optogenetic investigation of local adrenaline signaling effects on cardiac arrhythmia mechanisms
(2024-01-15)
Ventricular arrhythmias are one of the major causes of death worldwide, occurring especially in structurally remodeled hearts, but also in hereditary conditions, such as CPVT, in which mutations in RyR2 or Casq2 cause ...
Danger signaling pathways in aortic disease
(2024-02-19)
The aorta connects the heart to the peripheral circulation and organs. It is necessary for the regulation of hemodynamics and therefore, aortic disease affects all organs and the survival of the individual. In aortic valve ...
Establishing blood-based classifiers for decentralized and privacy-preserving disease prediction
(2024-04-08)
Big data is increasingly being generated across all sectors of medicine and high-dimensional omics data have been shown to be a powerful data space for AI applications that can assist in primary and differential diagnostics, ...
Identification of alpha-synuclein and ataxin-3 expression modifying compounds
(2024-02-16)
(noch nicht zugänglich / not yet accessible)