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Evaluation of Wolbachia depletion after antibiotic treatment using real-time PCR in Onchocerciasis and Lymphatic Filariasis, and analysis of genetic associations in Lymphatic Filariasis
(2011-11-15)
Two of the major filarial infections, onchocerciasis and LF, affect > 150 million people. Currently, control programs use yearly mass application of drugs that mainly kill microfilaria (Mf) with the aim to prevent uptake ...
Investigation of the symbiosis between filarial nematodes and their Wolbachia bacteria: analysing genes that are differentially expressed after loss of Wolbachia
(2012-11-19)
Filarial infections, caused by Brugia malayi, Wuchereria bancrofti and Onchocerca volvulus are a worldwide health problem in developing countries, causing elephantiasis or dermatitis and blindness. 1.3 billion people live ......
Ocular Onchocerciasis: The Role of Toll-Like Receptor-2 and Interferon-γ
(2010-03-17)
River Blindness is still highly prevalent in subsaharan Africa with millions of people suffering from the infection with Onchocerca volvulus. This filarial worm harbors the endosymbiont Wolbachia which was ...
Synthesis and Characterisation of wALAD Inhibitors and Novel ABAL Probes
(2016-10-12)
The here presented work comprises two projects with highly interdisciplinary topics in the chemical biology field. The development of novel small molecule ALAD inhibitors which might show their potential as novel antifilarial, ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......