E-Dissertationen: Search
Now showing items 1-3 of 3
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Intranukleäre Mobilität und Export der kleinen Untereinheit in humanen Zellen
(2018-06-18)
Die Ribosomenbiogenese ist ein essentieller Prozess aller lebender Zellen, da ohne funktionale Ribosomen die Proteinsynthese in der Zelle zusammenbricht. Da der Prozess der Ribosomenbiogenese demnach so wichtig ist, wurde ......
The endophytic fungus Stemphylium globuliferum – secondary metabolites and biological activities
(2018-01-22)
Fungi are a tremendous source of pharmaceutically significant compounds, e.g. the life saving immunosuppressant drug mycophenolic acid. The current project focused on the investigation of the mold fungus Stemphylium ......