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Evaluation of Wolbachia depletion after antibiotic treatment using real-time PCR in Onchocerciasis and Lymphatic Filariasis, and analysis of genetic associations in Lymphatic Filariasis
(2011-11-15)
Two of the major filarial infections, onchocerciasis and LF, affect > 150 million people. Currently, control programs use yearly mass application of drugs that mainly kill microfilaria (Mf) with the aim to prevent uptake ...
Identification of new molecular targets and antibiotics as novel strategies against filarial infections: Characterization of lipid II biosynthesis in Wolbachia endobacteria
(2019-06-05)
Wolbachia are obligate intracellular bacteria found in many arthropods and some filarial nematodes that are pathogenic in humans. The Wolbachia genomes are highly reduced, but encode proteins required for the synthesis of ......