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Biomarkers and Correlates of Aging
(2021-10-19)
The rapid aging of the global population, often accompanied by disabilities and various age-related diseases, is becoming a major public health burden (WHO 2015). Stimulating healthy aging is therefore of tremendous ...
Topics in Population Imaging: The Rhineland Study
(2022-07-29)
Population imaging is the large-scale data acquisition and analysis of medical images in population-based cohorts. When combined with other data acquired in the cohort, it provides the unique potential to characterise ...
Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism
(2023-12-07)
Visceral adipose tissue (VAT) is an endocrine organ critical for energy storage and metabolic homeostasis. It harbours a plethora of immune cells, which play an important role in maintaining tissue homeostasis. A large ...
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...
Die Auswirkung des Migrationshintergrundes auf das Outcome von Krebspatienten am Centrum für Integrierte Onkologie Bonn: Eine Matched-Pair-Analyse
(2023-12-11)
Hintergrund: Das Thema "Migration" ist insbesondere in den Industrieländern wie Deutschland in den letzten Jahren zu einem der dominierenden politischen Themen geworden. Auffallend ist, dass neue Daten ...
Komplikations- und Fehlermanagement am Beispiel von muskuloskelettalen Infektionen der unteren Extremität
(2023-01-09)
Die postoperative Wundinfektion ist eine gefürchtete Komplikation im Fachbereich der Orthopädie und Unfallchirurgie. Sie führt häufig zu einem schlechteren funktionellen Ergebnis für den Patienten und bedeutet einen hohen ...
Simplified intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging for liver lesion discrimination: An analysis of different analysis approaches
(2023-01-06)
Diffusion weighted imaging is one of the most promising non-invasive imaging techniques implemented in routine clinical practice and plays an important role in liver lesion characterization and discrimination. Using ...
Gibt es klinische Prädiktoren der neurogenen Dysfunktion des unteren Harntraktes bei Patienten mit Multipler Sklerose?
(2023-01-13)
Hintergrund: MS-Patienten entwickeln häufig neurogene Blasenfunktionsstörungen mit einem erhöhten Risiko für Schäden des oberen Harntraktes. Zur Diagnostik werden Miktionstagebücher, die Uroflowmetrie, der ...
Immunotherapeutic Approaches in Multiple Myeloma
(2023-12-12)
Checkpoint inhibition (CPI) has shown dramatic improvements in overall survival in many malignant diseases. However, in multiple myeloma (MM) the results were disappointing resulting in an early termination of clinical ...
Integrative Genome-Wide Analysis of Genomic and Epigenomic Data in Neuropsychiatric Disorders
(2023-01-20)
The neurobiological correlates for the development of affective disorder development are largely unknown. There is increasing evidence that epigenetic modifications e.g. DNA methylation play an important role in the ...