Fluorophordesign und FluoreszenzmarkierungSynthese funktionalisierter BODIPY-Derivate und Markierung von Purinrezeptor-Liganden
Fluorophordesign und Fluoreszenzmarkierung
Synthese funktionalisierter BODIPY-Derivate und Markierung von Purinrezeptor-Liganden
View/Type of Scholarly Publication
DissertationDate of Exam
15.02.2002Date of Publication
2002Advisor
Müller, Christa E.Co-Referee
Gütschow, MichaelMetadata
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Abstract
Adenosine receptors are G-protein-coupled receptors present in the cell membranes of many organs and tissues. Four different subtypes are known to date (A1, A2A, A2B, A3). Fluorescence-labeled ligands are becoming increasingly important for studies of receptor regulation and their function. New BODIPY derivatives were synthesized bearing different spacer lengths and various functional groups suitable for labeling of receptor ligands. The BODIPY-derivatives have been attached to adenosine receptor antagonists. Labeled compounds were investigated in radioligand binding studies. Some products retained high receptor affinity and were strongly fluoreccent.
Subjects
BODIPY, Purinrezeptoren, Adenosinrezeptoren, Fluoreszenzmarkierung
Classification (DDC)
540 Chemie 610 Medizin, GesundheitFreudenthal, Sven Jan: Fluorophordesign und Fluoreszenzmarkierung : Synthese funktionalisierter BODIPY-Derivate und Markierung von Purinrezeptor-Liganden. - Bonn, 2002. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5n-00382
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5n-00382
@phdthesis{handle:20.500.11811/1803,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5n-00382,
author = {{Sven Jan Freudenthal}},
title = {Fluorophordesign und Fluoreszenzmarkierung : Synthese funktionalisierter BODIPY-Derivate und Markierung von Purinrezeptor-Liganden},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2002,
note = {Adenosine receptors are G-protein-coupled receptors present in the cell membranes of many organs and tissues. Four different subtypes are known to date (A1, A2A, A2B, A3). Fluorescence-labeled ligands are becoming increasingly important for studies of receptor regulation and their function. New BODIPY derivatives were synthesized bearing different spacer lengths and various functional groups suitable for labeling of receptor ligands. The BODIPY-derivatives have been attached to adenosine receptor antagonists. Labeled compounds were investigated in radioligand binding studies. Some products retained high receptor affinity and were strongly fluoreccent.},
url = {https://hdl.handle.net/20.500.11811/1803}
}
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5n-00382,
author = {{Sven Jan Freudenthal}},
title = {Fluorophordesign und Fluoreszenzmarkierung : Synthese funktionalisierter BODIPY-Derivate und Markierung von Purinrezeptor-Liganden},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2002,
note = {Adenosine receptors are G-protein-coupled receptors present in the cell membranes of many organs and tissues. Four different subtypes are known to date (A1, A2A, A2B, A3). Fluorescence-labeled ligands are becoming increasingly important for studies of receptor regulation and their function. New BODIPY derivatives were synthesized bearing different spacer lengths and various functional groups suitable for labeling of receptor ligands. The BODIPY-derivatives have been attached to adenosine receptor antagonists. Labeled compounds were investigated in radioligand binding studies. Some products retained high receptor affinity and were strongly fluoreccent.},
url = {https://hdl.handle.net/20.500.11811/1803}
}
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