An anti-CD30 immunocytokine with combined IL-2 and IL-12 domains enhances anti-tumour immunity
An anti-CD30 immunocytokine with combined IL-2 and IL-12 domains enhances anti-tumour immunity
dc.contributor.advisor | Abken, Hinrich | |
dc.contributor.author | Zuther, Martin | |
dc.date.accessioned | 2020-04-15T15:11:54Z | |
dc.date.available | 2020-04-15T15:11:54Z | |
dc.date.issued | 24.09.2010 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11811/4588 | |
dc.description.abstract | Classical Hodgkin’s lymphoma is one of the most curable cancers today. However, non-responders, tumour relapses and long-term toxicities of the treatment make it necessary to look for alternative drugs. In this study, we have generated a novel immunocytokine that aims to overcome the misguided TH2 immune response in Hodgkin’s lymphoma by targeting CD30 on the surface of the malignant Hodgkin-Reed-Sternberg cells, and by combining IL-2 and IL-12 domains in one molecule. This immunocytokine induces resting natural killer cells to specific lysis of CD30⁺ tumour cells, exhibits superior cytokine activity compared to immunocytokines with a single cytokine domain, and inhibits tumour growth in immunocompetent mice. | en |
dc.language.iso | eng | |
dc.rights | In Copyright | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.subject | Pharmakologie | |
dc.subject | Immuntherapie | |
dc.subject | Krebsmittel | |
dc.subject | Fusionsprotein | |
dc.subject | Antikörperhaltiges Arzneimittel | |
dc.subject | Zytokine | |
dc.subject | pharmacology | |
dc.subject | immunotherapy | |
dc.subject | anti-cancer drug | |
dc.subject | fusion protein | |
dc.subject | antibody-containing drug | |
dc.subject | cytokines | |
dc.subject.ddc | 570 Biowissenschaften, Biologie | |
dc.subject.ddc | 610 Medizin, Gesundheit | |
dc.title | An anti-CD30 immunocytokine with combined IL-2 and IL-12 domains enhances anti-tumour immunity | |
dc.type | Dissertation oder Habilitation | |
dc.publisher.name | Universitäts- und Landesbibliothek Bonn | |
dc.publisher.location | Bonn | |
dc.rights.accessRights | openAccess | |
dc.identifier.urn | https://nbn-resolving.org/urn:nbn:de:hbz:5N-21829 | |
dc.relation.isbn | 978-3-86853-433-7 | |
ulbbn.pubtype | Erstveröffentlichung | |
ulbbnediss.affiliation.name | Rheinische Friedrich-Wilhelms-Universität Bonn | |
ulbbnediss.affiliation.location | Bonn | |
ulbbnediss.thesis.level | Dissertation | |
ulbbnediss.dissID | 2182 | |
ulbbnediss.date.accepted | 19.03.2010 | |
ulbbnediss.fakultaet | Mathematisch-Naturwissenschaftliche Fakultät | |
dc.contributor.coReferee | Mohr, Klaus |
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