Fakultäten der Universität Bonn: Suche
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Interesse an der Natur bei Kindergarten- und Grundschulkindern: Studien zur Gestaltung und Wirkung des Forschenden Lernens an außerschulischen Lernorten
(2020-06-18)
Interesse gilt als zentrale motivationale Voraussetzung für das Lernen. Auch für eine gesunde Persönlichkeitsentwicklung ist die Ausprägung und Entwicklung von Interessen notwendig. Bislang ist jedoch kaum erforscht, wie ...
Untersuchung der molekularen Mechanismen einer intrinsischen sowie Matrix-vermittelten Cisplatinresistenz in W1 Ovarialkarzinomzellen
(2021-06-01)
Die Resistenzbildung von Tumoren gegen antineoplastische Medikamente bildet das Haupthindernis der klinischen Behandlung von Krebserkrankungen und unterstreicht die dringende Notwendigkeit, innovative Therapien zu entwickeln. ...
Clickmers and Aptamers as versatile tools for drug testing and fluorescence microscopy techniques
(2020-12-01)
Δ9-tetrahydrocannabinol (THC) is the main psychotropic compound of the plant cannabis sativa. THC consumption provokes several physical impairments, which in turn might reduce the capability of consumers, to ...
Multiprofessionelles Medikationsmanagement für ambulante Patienten mit intravenös applizierter Tumortherapie
(2020-11-02)
Bei ambulanten Tumorpatienten ist die Arzneimitteltherapiesicherheit eine stetige Herausforderung. Ein multiprofessionelles Medikationsmanagement kann zu einer angemessenen Arzneimitteltherapie und einem fehlerfreien ...
Role of Endothelin-1 in the Brown Adipose Tissue
(2021-06-22)
ET-1 was shown to inhibit adipogenesis in murine mesenchymal stem cells derived from new-born brown adipose tissue in vitro and antagonism of Endothelin-1 (ET-1) signaling at the respective level of the Endothelin-1 receptor ...
The Role of TRIM71 in Male Germ Cell Development
(2020-09-02)
Germ cells are the key to continuation of life as they are the unique cell lineage capable to transfer the complete genetic information to the next generation. Both, infertility and testicular cancers are usually originating ......
Inducing immunity to liver stage malaria through endogenous tissue resident memory cells
(2020-12-16)
Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can respond rapidly to infection due to their strategic location. Within the liver, TRM cells can induce effective protection against ...
The role of YAP signaling in thermogenic adiposetissues
(2021-01-02)
One of major metabolic organs, brown adipose tissue (BAT), is responsible for energy expenditure through uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis, which has been considered a promising pharmacological ...
Electrophysiological and pharmacological in vivo characterization of EEG fingerprints / biomarkers in AD mouse models
(2021-01-19)
Alzheimer’s disease (AD) is a major leading cause of deaths worldwide with underlying conditions of dementia and cognitive decline mostly in older age patients (≥ 65 years). Currently, there are approximately 50 million ...
Selection of an aptamer and development of a genetic device to control mRNA stability in response to light
(2022-02-09)
Artificial autocatalytic RNA molecules, so-called aptazymes, are utilized as genetic devices to study and influence biological processes. These genetic devices consist of the autocatalytic RNA part, the ribozyme, and a ...