Faculties of University Bonn: Search
Now showing items 621-630 of 732
Analysis of Multitarget Activities and Assay Interference Characteristics of Pharmaceutically Relevant Compounds
(2019-05-29)
The availability of large amounts of data in public repositories provide a useful source of knowledge in the field of drug discovery. Given the increasing sizes of compound databases and volumes of activity data, computational ...
A water storage reanalysis over the European continent: assimilation of GRACE data into a high-resolution hydrological model and validation
(2019-04-18)
Continental water storage and redistribution within the Earth’s system are key variables of the terrestrial water cycle. Changes in water storage and fluxes may affect resources for drinking water and irrigation, lead ...
African nightshade and African spinach: A neglected and underutilized resource with significant potential to manage plant-parasitic nematodes
(2019-05-07)
African indigenous vegetables (AIV) are essential for dietary diversification and ensuring nutritional requirements for people in sub-Sahara Africa. AIV have been largely marginalized by agriculture research, yet they are ......
In Afrika heimische Blattgemüse (AIV) sind essentielle Komponenten einer reichhaltigen und ausreichenden Ernährung der Einwohner sub-Sahara Afrikas. Obwohl AIV ausdauernd und tolerant gegen wechselnde Umweltbedingungen ......
In Afrika heimische Blattgemüse (AIV) sind essentielle Komponenten einer reichhaltigen und ausreichenden Ernährung der Einwohner sub-Sahara Afrikas. Obwohl AIV ausdauernd und tolerant gegen wechselnde Umweltbedingungen ......
On some Geometric Search Problems: Algorithms, Complexity, Computability
(2020-11-25)
This thesis considers four search problems which are related to or emerge from a geometric context. Each search problem is examined in a separate chapter; these four chapters are framed by an introduction and a conclusion ...
The Effects of Orciprenaline on the Contractility of Isolated Cardiomyocytes under Septic Conditions Mediated by Lipopolysaccharide
(2018-07-06)
The septic cardiomyopathy is associated with a high morbidity and mortality. In a sepsis, the contractility of a cardiomyocyte is reduced significantly. Consecutively, the cardiac output of the heart is compromised. This ...
The role of the transcription factor BCL11A in midbrain dopaminergic neurons
(2022-03-11)
Midbrain dopaminergic (mDA) neurons are located in three midbrain nuclei, the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field (RRF). mDA neurons are diverse in their developmental origin, their ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
Dopaminerge Neuronen des Mittelhirns (mDA) befinden sich in drei Kerngebieten des Mittelhirns, der Substantia nigra (SN), dem ventralen tegmentalen Areal (VTA) und dem retrorubralen Feld (RRF). mDA-Neurone unterscheiden ......
The Impact of CD44 and Osteopontin on Hematopoiesis
(2021-10-25)
Hematopoiesis is the process, which enables the replenishment of blood cellular components in mammals throughout their lifespan. Hematopoietic stem cells (HSC), which reside within the bone marrow (BM), are the primary ...
Electrostatic anchoring of SNAP25 to the plasma membrane
(2021-07-21)
Neurotransmission is based on incredibly rapid membrane trafficking cycles, mediating the release of neurotransmitters. The fusion machinery of the well-studied SNARE protein complex ensures the speed and precision of ...
Validierung und forensische Anwendung chromatographisch-massenspektrometrischer Methoden zum Nachweis von klassischen illegalen Drogen, neuen psychoaktiven Substanzen und Arzneistoffen in verschiedenen Matrices am Beispiel von Heroin, Cathinon-Derivaten und Propofol
(2018-06-12)
Im Rahmen der forensisch-toxikologischen Begutachtung sind neben den klassischen illegalen Drogen auch diverse Medikamente sowie neue psychoaktive Substanzen von Relevanz. Für den gerichtsverwertbaren Nachweis dieser ...
Modulation der Signaltransduktion des muskarinischen M1-Rezeptors mittels orthosterischer und dualsterischer Liganden
(2018-09-26)
Muskarinische Acetylcholin Rezeptoren (mAChRs) gehören zur Superfamilie der G Protein-gekoppelten Rezeptoren (GPCRs). Der Subtyp 1 der mAChRs (M1-mAChR) koppelt bevorzugt an G Proteine der Gq-Familie, kann jedoch promiskuitiv ...