Fachgruppe Pharmazie: Auflistung Fachgruppe Pharmazie nach Erscheinungsdatum

Anzeige der Dokumente 1-5 von 5

    • Irreversible Antagonists for the Adenosine A2B Receptor 

      Temirak, Ahmed; Schlegel, Jonathan; Voss, Jan; Vaaßen, Victoria; Vielmuth, Christin; Claff, Tobias; Müller, Christa (2022-06-13)
      Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ...

    • Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy 

      Kraft, Fabian; Hanl, Maria; Feller, Felix; Schäker-Hübner, Linda; Hansen, Finn (2023-02-25)
      Histone deacetylases (HDACs) play a key role in the control of transcription, cell prolifer- ation, and migration. FDA-approved histone deacetylase inhibitors (HDACi) demonstrate clinical efficacy in the treatment of ...

    • A Systematic Database Approach to Identify Companion Diagnostic Testing in Clinical Trials under the New In Vitro Diagnostic Medical Devices Regulation 

      Wollenhaupt, Clara; Sudhop, Thomas; Knoess, Werner (2023-06-12)
      The European Union In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746 (IVDR) introduces companion diagnostics (CDx) as a new legal term. CDx are applied in combination with a medicinal product to identify patient ...

    • Development of the first geldanamycin-based HSP90 degraders 

      Wurnig, Silas; Vogt, Melina; Hogenkamp, Julian; Dienstbier, Niklas; Borkhardt, Arndt; Bhatia, Sanil; Hansen, Finn (2023-06-28)
      Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs. A new approach involving proteolysis-targeting ...

    • Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations 

      Becker, Tim; Heitkötter, Jan; Krome, Anna K.; Schiefer, Andrea; Pfarr, Kenneth; Ehrens, Alexandra; Grosse, Miriam; Sandargo, Birthe; Stammberger, Ingo; Stadler, Marc; Hübner, Marc P.; Kehraus, Stefan; Hoerauf, Achim; Wagner, Karl G. (2024-03-12)
      Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates ...