Development of protein loaded microparticles and nanoparticles for antigen delivery

Abstract

An innovative approach of developing modern adjuvants is the design of particulate antigen delivery systems. These, typically polymeric, particles that are in a size range of micro- and nanoparticles can be used as drug carrier systems. Such drug carriers can target antigen presenting cells, which is crucial for long-lasting immunity. The aim of this work was the development and characterization of polymeric micro- and nanoparticles for the antigen delivery using biodegradable and biocompatible polymers. In this work poly(D,L-lactide-co-glycolide) (PLGA) was used as a polymer, because PLGA-microparticles and PLGA-nanoparticles already showed a potential to be used as vaccine adjuvants.